Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 19/20 | 0.62 |
| ▸ | EGFR | P00533 | 1/20 | 0.62 |
| ▸ | INSR | P06213 | 6/20 | 0.57 |
| ▸ | IGF1R | P08069 | 6/20 | 0.57 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18812802 | 0.94 | ALK (0.67) | ALKEGFRINSRIGF1RPTK2 | |
| SCHEMBL20472805 | 0.90 | ALK (0.66) | ALKEGFRINSRIGF1RPTK2 | |
| SCHEMBL17410889 | 0.87 | ALK (0.79) | ALKEGFRINSRIGF1RPTK2 | |
| SCHEMBL17411082 | 0.85 | ALK (0.80) | ALKEGFRINSRIGF1R | |
| SCHEMBL30761517 | 0.83 | ALK (0.82) | ALKEGFRINSRIGF1RPTK2 | |
| SCHEMBL24818145 | 0.83 | ALK (0.79) | ALKEGFRINSRIGF1R | |
| SCHEMBL24207615 | 0.78 | ALK (0.73) | ALKEGFRINSRIGF1RPTK2 | |
| SCHEMBL14866190 | 0.78 | ALK (0.73) | ALKEGFRINSRIGF1RPTK2 | |
| SCHEMBL30497500 | 0.77 | EGFR (0.65) | ALKEGFR | |
| SCHEMBL26500041 | 0.77 | EGFR (0.65) | ALKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170129909-A1 | SPIROCYCLIC ARYL PHOSPHORUS OXIDE AND ARYL PHOSPHORUS SULFIDE | QUILU PHARMACEUTICAL CO., LTD. (CN) | 2017-05-11 | — | — | US | disclosed |
| US-20170129909-A1 | SPIROCYCLIC ARYL PHOSPHORUS OXIDE AND ARYL PHOSPHORUS SULFIDE | QUILU PHARMACEUTICAL CO., LTD. (CN) | 2017-05-11 | — | — | US | disclosed |
| WO-2016000581-A1 | SPIROCYCLIC ARYL PHOSPHORUS OXIDE AND ARYL PHOSPHORUS SULFIDE | 南京明德新药研发股份有限公司 | 2016-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170129909-A1 | SPIROCYCLIC ARYL PHOSPHORUS OXIDE AND ARYL PHOSPHORUS SULFIDE | ALK, ROS1, ARSA | ALK 1/4885EGFR 209/4885INSR 993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.