Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1739767 | 0.91 | S1PR1 (0.35) | — | |
| SCHEMBL12181281 | 0.91 | — | — | |
| SCHEMBL1739349 | 0.77 | S1PR1 (0.38) | — | |
| SCHEMBL1738478 | 0.76 | S1PR1 (0.39) | SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL2473086 | 0.72 | ALDH1A1 (0.35) | LMNASMN1; SMN2ALDH1A1KDM4ETP53 | |
| SCHEMBL1741740 | 0.72 | ALDH1A1 (0.42) | LMNASMN1; SMN2ALDH1A1KDM4ETP53 | |
| SCHEMBL1739399 | 0.71 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL1739410 | 0.69 | SMN1; SMN2 (0.42) | LMNASMN1; SMN2ALDH1A1KDM4ETP53 | |
| SCHEMBL1739901 | 0.69 | S1PR1 (0.46) | — | |
| SCHEMBL1739255 | 0.68 | KMT2A (0.44) | LMNASMN1; SMN2ALDH1A1KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2390252-A1 | New pyrazole derivatives | Almirall, S.A. (ES) | 2011-11-30 | — | — | EP | disclosed |
| WO-2011144338-A1 | PYRAZOLE DERIVATIVES AS S1P1 AGONISTS | ALMIRALL, S.A. (ES) | 2011-11-24 | — | — | WO | disclosed |