Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 5/20 | 0.59 |
| ▸ | ITK | Q08881 | 4/20 | 0.59 |
| ▸ | JAK3 | P52333 | 11/20 | 0.58 |
| ▸ | SYK | P43405 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | JAK2 | O60674 | 3/20 | 0.51 |
| ▸ | JAK1 | P23458 | 3/20 | 0.51 |
| ▸ | PLCG1 | P19174 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17412959 | 0.89 | SYK (0.57) | JAK3SYKCYP2C9JAK2JAK1 | |
| SCHEMBL17413158 | 0.87 | BTK (0.61) | BTKITKJAK3JAK2PLCG1 | |
| SCHEMBL31061214 | 0.87 | BTK (0.60) | BTKITKJAK3SYKPLCG1 | |
| SCHEMBL15740631 | 0.87 | BTK (0.60) | BTKITKJAK3SYKPLCG1 | |
| SCHEMBL17413148 | 0.86 | JAK3 (0.58) | JAK3SYKJAK2JAK1 | |
| SCHEMBL17413051 | 0.85 | BTK (0.58) | BTKITKJAK3SYKCYP2C9 | |
| SCHEMBL15740604 | 0.85 | JAK3 (0.64) | BTKITKJAK3PLCG1 | |
| SCHEMBL17412970 | 0.84 | JAK3 (0.70) | JAK3JAK2JAK1 | |
| SCHEMBL17413159 | 0.84 | JAK3 (0.50) | JAK3SYKCYP2C9JAK2JAK1 | |
| SCHEMBL17413143 | 0.84 | ITK (0.56) | BTKITKJAK3PLCG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016000615-A1 | HETEROARYL COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2016-01-07 | — | — | WO | disclosed |