Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | JAK3 | P52333 | 18/20 | 0.55 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | JAK1 | P23458 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17412969 | 0.89 | BTK (0.59) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL17413159 | 0.85 | JAK3 (0.50) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL17412962 | 0.84 | JAK3 (0.70) | JAK3JAK2JAK1 | |
| SCHEMBL28089808 | 0.82 | SYK (0.65) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL17413148 | 0.79 | JAK3 (0.58) | SYKJAK3JAK2JAK1 | |
| SCHEMBL17413040 | 0.78 | JAK3 (0.58) | JAK3JAK2JAK1 | |
| SCHEMBL17413029 | 0.78 | JAK3 (0.58) | JAK3JAK2JAK1 | |
| SCHEMBL17412970 | 0.78 | JAK3 (0.70) | JAK3JAK2JAK1 | |
| SCHEMBL2279041 | 0.77 | SYK (0.83) | SYKCYP2C9JAK3JAK2JAK1 | |
| SCHEMBL17413145 | 0.77 | JAK3 (0.49) | JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016000615-A1 | HETEROARYL COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2016-01-07 | — | — | WO | disclosed |