Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 9/20 | 0.51 |
| ▸ | BTK | Q06187 | 8/20 | 0.51 |
| ▸ | PLCG1 | P19174 | 7/20 | 0.49 |
| ▸ | EGFR | P00533 | 4/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.45 |
| ▸ | TEK | Q02763 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17412999 | 0.89 | PLCG1 (0.54) | ITKBTKPLCG1EGFR | |
| SCHEMBL17412911 | 0.87 | PLCG1 (0.62) | ITKBTKPLCG1 | |
| SCHEMBL17413223 | 0.85 | BTK (0.49) | ITKBTKPLCG1EGFR | |
| SCHEMBL17412905 | 0.78 | JAK3 (0.49) | ITKBTKPLCG1EGFR | |
| SCHEMBL17412904 | 0.77 | BTK (0.49) | ITKBTKPLCG1EGFR | |
| SCHEMBL17412995 | 0.77 | BTK (0.54) | ITKBTKPLCG1 | |
| SCHEMBL17413222 | 0.77 | PLCG1 (0.55) | ITKBTKPLCG1 | |
| SCHEMBL17413105 | 0.76 | BTK (0.47) | ITKBTKPLCG1 | |
| SCHEMBL17413071 | 0.76 | BTK (0.49) | ITKBTKPLCG1 | |
| SCHEMBL17413038 | 0.76 | PLCG1 (0.52) | ITKBTKPLCG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016000615-A1 | HETEROARYL COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2016-01-07 | — | — | WO | disclosed |