Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.72 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.70 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | GAA | P10253 | 3/20 | 0.66 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | BLM | P54132 | 1/20 | 0.64 |
| ▸ | PTGES | O14684 | 1/20 | 0.64 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16323913 | 0.89 | ALDH1A1 (0.81) | TSHRALDH1A1KDM4ETDP1PKM | |
| SCHEMBL17413885 | 0.88 | TSHR (0.79) | TSHRALDH1A1KDM4ETDP1GPBAR1 | |
| SCHEMBL10113207 | 0.88 | TSHR (0.78) | TSHRALDH1A1KDM4ETDP1PKM | |
| SCHEMBL17413836 | 0.87 | ALDH1A1 (0.78) | TSHRALDH1A1KDM4ETDP1PKM | |
| SCHEMBL19752621 | 0.87 | TSHR (0.76) | TSHRALDH1A1PKMGAAADORA2B | |
| SCHEMBL19752620 | 0.87 | TSHR (0.76) | TSHRALDH1A1PKMGAAADORA2B | |
| SCHEMBL17413880 | 0.86 | TSHR (0.76) | TSHRALDH1A1KDM4ETDP1GPBAR1 | |
| SCHEMBL10113673 | 0.84 | ALDH1A1 (0.74) | TSHRALDH1A1KDM4ETDP1PKM | |
| SCHEMBL15176799 | 0.84 | ALDH1A1 (1.00) | TSHRALDH1A1KDM4ETDP1PKM | |
| SCHEMBL10113526 | 0.84 | ALDH1A1 (0.74) | TSHRALDH1A1KDM4ETDP1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016004028-A1 | 2-OXOPYRIMIDINE-5-CARBOXYLATE DERIVATIVES FOR TREATING THYROID DISEASES | LATIF RAUF (US) | 2016-01-07 | — | — | WO | disclosed |