Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 11/20 | 0.59 |
| ▸ | BCR | P11274 | 8/20 | 0.59 |
| ▸ | BRAF | P15056 | 4/20 | 0.57 |
| ▸ | LYN | P07948 | 3/20 | 0.57 |
| ▸ | CSK | P41240 | 2/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.57 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | FYN | P06241 | 1/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.57 |
| ▸ | ARAF | P10398 | 1/20 | 0.57 |
| ▸ | NQO2 | P16083 | 1/20 | 0.57 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.57 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.57 |
| ▸ | ABL2 | P42684 | 1/20 | 0.57 |
| ▸ | FRK | P42685 | 1/20 | 0.57 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.57 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.57 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17426694 | 1.00 | ABL1 (0.59) | ABL1BCRBRAFLYNCSK | |
| SCHEMBL3814061 | 0.94 | CSK (0.59) | ABL1BCRBRAFLYNCSK | |
| SCHEMBL15859845 | 0.92 | CSK (0.58) | ABL1BCRBRAFLYNCSK | |
| SCHEMBL17420203 | 0.92 | CSK (0.58) | ABL1BCRBRAFLYNCSK | |
| SCHEMBL15859876 | 0.92 | CSK (0.58) | ABL1BCRBRAFLYNCSK | |
| SCHEMBL16603010 | 0.89 | CSK (0.59) | ABL1BCRBRAFLYNCSK | |
| SCHEMBL17313603 | 0.89 | ABL1 (0.57) | ABL1BCRBRAFLYNCSK | |
| SCHEMBL15860133 | 0.89 | ABL1 (0.57) | ABL1BCRBRAFLYNCSK | |
| SCHEMBL15860135 | 0.89 | ABL1 (0.57) | ABL1BCRBRAFLYNCSK | |
| SCHEMBL15859840 | 0.88 | BRAF (0.61) | ABL1BCRBRAFEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9403823-B2 | Protein kinase inhibitors | ORIBASE PHARMA (FR) | 2016-08-02 | — | — | US | disclosed |
| US-20160009709-A1 | PROTEIN KINASE INHIBITORS | ORIBASE PHARMA (FR) | 2016-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160009709-A1 | PROTEIN KINASE INHIBITORS | MAP3K20, MAP3K1, MAP3K2 | ABL1 128/4885BCR 1053/4885BRAF 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.