Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSK | P41240 | 3/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.59 |
| ▸ | ABL1 | P00519 | 11/20 | 0.57 |
| ▸ | BCR | P11274 | 7/20 | 0.57 |
| ▸ | LYN | P07948 | 3/20 | 0.55 |
| ▸ | BRAF | P15056 | 2/20 | 0.55 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.55 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | FYN | P06241 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | ARAF | P10398 | 1/20 | 0.55 |
| ▸ | NQO2 | P16083 | 1/20 | 0.55 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.55 |
| ▸ | ABL2 | P42684 | 1/20 | 0.55 |
| ▸ | FRK | P42685 | 1/20 | 0.55 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.55 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13260779 | 0.93 | CSK (0.51) | CSKMAPK14ABL1BCRLYN | |
| SCHEMBL15382290 | 0.91 | CSK (0.59) | CSKMAPK14ABL1BCRLYN | |
| SCHEMBL3814061 | 0.90 | CSK (0.59) | CSKMAPK14ABL1BCRLYN | |
| SCHEMBL17420206 | 0.89 | ABL1 (0.59) | CSKMAPK14ABL1BCRLYN | |
| SCHEMBL17426694 | 0.89 | ABL1 (0.59) | CSKMAPK14ABL1BCRLYN | |
| SCHEMBL17313610 | 0.83 | CSK (0.56) | CSKMAPK14ABL1BCRLYN | |
| SCHEMBL15859941 | 0.83 | CSK (0.56) | CSKMAPK14ABL1BCRLYN | |
| SCHEMBL3708724 | 0.82 | CSK (0.62) | CSKMAPK14ABL1BCRLYN | |
| SCHEMBL17420231 | 0.82 | CSK (0.60) | CSKMAPK14ABL1BCRLYN | |
| SCHEMBL15372817 | 0.82 | CSK (0.60) | CSKMAPK14ABL1BCRLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396325-B1 | DERIVATIVES OF AZAINDOLES AS INHIBITORS OF PROTEIN KINASES ABL AND SRC | ORIBASE PHARMA (FR) | 2015-04-01 | — | — | EP | disclosed |