Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRB | P23467 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.36 |
| ▸ | AKT1 | P31749 | 3/20 | 0.36 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.33 |
| ▸ | FEN1 | P39748 | 2/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1742500 | 0.81 | CDK2 (0.38) | CDK2AKT1CTSAGSK3BDYRK1A | |
| SCHEMBL1742112 | 0.80 | PPARG (0.39) | PTPRBCTSAPPARGPPARAS1PR3 | |
| SCHEMBL1741924 | 0.80 | CTSA (0.36) | CDK2AKT1CTSAGSK3BDYRK1A | |
| SCHEMBL13286160 | 0.79 | AKT1 (0.37) | PTPRBCDK2AKT1GSK3BDYRK1A | |
| SCHEMBL1744751 | 0.77 | CDK2 (0.35) | PTPRBCDK2AKT1GSK3BDYRK1A | |
| SCHEMBL2544079 | 0.76 | CDK2 (0.36) | CDK2AKT1CTSAGSK3BDYRK1A | |
| SCHEMBL2546671 | 0.76 | CDK2 (0.35) | PTPRBCDK2AKT1GSK3BDYRK1A | |
| SCHEMBL2549646 | 0.76 | AKT1 (0.42) | PTPRBCDK2AKT1GSK3BDYRK1A | |
| SCHEMBL2550295 | 0.75 | AKT1 (0.40) | PTPRBCDK2AKT1GSK3BDYRK1A | |
| SCHEMBL2550309 | 0.75 | AKT1 (0.40) | PTPRBCDK2AKT1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387570-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | Amgen, Inc (US) | 2011-11-23 | — | — | EP | disclosed |
| WO-2010083246-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2010-07-22 | — | — | WO | disclosed |