Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefotaxime. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | PPARG | P37231 | 2/20 | 1.00 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 1.00 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 1.00 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 1.00 |
| ▸ | ALB | P02768 | 1/20 | 1.00 |
| ▸ | HTR2C | P28335 | 1/20 | 0.87 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.86 |
| ▸ | APEX1 | P27695 | 3/20 | 0.86 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.86 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.86 |
| ▸ | LMNA | P02545 | 2/20 | 0.86 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.86 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.86 |
| ▸ | PKM | P14618 | 1/20 | 0.86 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.86 |
| ▸ | POLB | P06746 | 1/20 | 0.86 |
| ▸ | RECQL | P46063 | 1/20 | 0.86 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefotaxime SCHEMBL10748430 | 1.00 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL2220120 | 1.00 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL1583477 | 1.00 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL10337429 | 1.00 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL3731937 | 1.00 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL3731931 | 1.00 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL5441797 | 1.00 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL9682785 | 1.00 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL16072837 | 1.00 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL9395572 | 1.00 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3534900-A1 | METHODS AND COMPOSITIONS FOR ATTENUATING ANTIBIOTIC RESISTANCE | Synthetic Biologics, Inc. (US) | 2019-09-11 | — | — | EP | disclosed |
| EP-3474885-A1 | MICROBIOME PROTECTION FROM ORAL ANTIBIOTICS | Synthetic Biologics, Inc. (US) | 2019-05-01 | — | — | EP | disclosed |
| WO-2018175414-A1 | BETA-LACTAMASE FORMULATIONS | SYNTHETIC BIOLOGICS, INC. (US) | 2018-09-27 | — | — | WO | disclosed |
| EP-3265119-A1 | SAFE AND EFFECTIVE BETA-LACTAMASE DOSING FOR MICROBIOME PROTECTION | Synthetic Biologics Inc. (US) | 2018-01-10 | — | — | EP | disclosed |
| WO-2018005606-A1 | MICROBIOME PROTECTION FROM ORAL ANTIBIOTICS | SYNTHETIC BIOLOGICS, INC. (US) | 2018-01-04 | — | — | WO | disclosed |
| EP-3261662-A1 | CARBAPENEMASES FOR USE WITH ANTIBIOTICS FOR THE PROTECTION OF THE INTESTINAL MICROBIOME | Synthetic Biologics Inc. (US) | 2018-01-03 | — | — | EP | disclosed |
| EP-3236993-A1 | METHODS AND COMPOSITIONS FOR INHIBITING OR PREVENTING ADVERSE EFFECTS OF ORAL ANTIBIOTICS | Synthetic Biologics Inc. (US) | 2017-11-01 | — | — | EP | disclosed |
| EP-3166959-A1 | TARGETING PEPTIDES THAT BIND S. MUTANS, CONSTRUCTS COMPRISING SUCH PEPTIDES AND USES THEREOF | C3 Jian, Inc. (US) | 2017-05-17 | — | — | EP | disclosed |
| WO-2016144856-A1 | SAFE AND EFFECTIVE BETA-LACTAMASE DOSING FOR MICROBIOME PROTECTION | SYNTHETIC BIOLOGICS, INC. (US) | 2016-09-15 | — | — | WO | disclosed |
| WO-2016137993-A1 | CARBAPENEMASES FOR USE WITH ANTIBIOTICS FOR THE PROTECTION OF THE INTESTINAL MICROBIOME | SYNTHETIC BIOLOGICS, INC. (US) | 2016-09-01 | — | — | WO | disclosed |
| WO-2016105498-A1 | METHODS AND COMPOSITIONS FOR INHIBITING OR PREVENTING ADVERSE EFFECTS OF ORAL ANTIBIOTICS | SYNTHETIC BIOLOGICS, INC. (US) | 2016-06-30 | — | — | WO | disclosed |
| WO-2016007551-A1 | TARGETING PEPTIDES THAT BIND S. MUTANS, CONSTRUCTS COMPRISING SUCH PEPTIDES AND USES THEREOF | C3 JIAN, INC. (US) | 2016-01-14 | — | — | WO | disclosed |