Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefotaxime. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | PPARG | P37231 | 2/20 | 1.00 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 1.00 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 1.00 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 1.00 |
| ▸ | ALB | P02768 | 1/20 | 1.00 |
| ▸ | HTR2C | P28335 | 1/20 | 0.87 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.86 |
| ▸ | APEX1 | P27695 | 3/20 | 0.86 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.86 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.86 |
| ▸ | LMNA | P02545 | 2/20 | 0.86 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.86 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.86 |
| ▸ | PKM | P14618 | 1/20 | 0.86 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.86 |
| ▸ | POLB | P06746 | 1/20 | 0.86 |
| ▸ | RECQL | P46063 | 1/20 | 0.86 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.86 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefotaxime SCHEMBL5441797 | 1.00 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL2220120 | 1.00 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL17422140 | 1.00 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL1583477 | 1.00 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL10748430 | 1.00 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL3731937 | 1.00 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL9395572 | 1.00 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL15410 | 1.00 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL14594281 | 1.00 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL16072837 | 1.00 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070004916-A1 | Process for the production of cefotaxime sodium | WOCKHARDT LIMITED | 2007-01-04 | — | — | US | claimed |
| EP-1704153-A2 | IMPROVED PROCESS FOR THE PRODUCTION OF CEFOTAXIME SODIUM | Wockhardt Limited (IN) | 2006-09-27 | — | — | EP | claimed |
| WO-2005076694-A2 | IMPROVED PROCESS FOR THE PRODUCTION OF CEFOTAXIME SODIUM | WOCKHARDT LIMITED (IN) | 2005-08-25 | — | — | WO | claimed |
| EP-0023453-B1 | PROCESS FOR THE PREPARATION OF DERIVATIVES OF 7-(2-ARYL)-2-HYDROXYIMINO-ACETAMIDO CEPHALOSPORANIC ACID | ROUSSEL-UCLAF (FR) | 1983-11-16 | — | — | EP | claimed |
| EP-0001024-B1 | CRYSTALLINE FORM OF THE SODIUM SALT OF AN OXYIMINO DERIVATIVE OF THE 7-AMINOTHIAZOLYLACETAMIDO-CEPHALOSPORANIC ACID, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT | ROUSSEL-UCLAF (FR) | 1981-01-21 | — | — | EP | claimed |
| US-20070004916-A1 | Process for the production of cefotaxime sodium | WOCKHARDT LIMITED | 2007-01-04 | — | — | US | disclosed |
| US-20070004916-A1 | Process for the production of cefotaxime sodium | WOCKHARDT LIMITED | 2007-01-04 | — | — | US | disclosed |
| EP-1704153-A2 | IMPROVED PROCESS FOR THE PRODUCTION OF CEFOTAXIME SODIUM | Wockhardt Limited (IN) | 2006-09-27 | — | — | EP | disclosed |
| EP-1704153-A2 | IMPROVED PROCESS FOR THE PRODUCTION OF CEFOTAXIME SODIUM | Wockhardt Limited (IN) | 2006-09-27 | — | — | EP | disclosed |
| WO-2005076694-A3 | IMPROVED PROCESS FOR THE PRODUCTION OF CEFOTAXIME SODIUM | WOCKHARDT LTD (IN) | 2005-12-01 | — | — | WO | disclosed |
| WO-2005076694-A2 | IMPROVED PROCESS FOR THE PRODUCTION OF CEFOTAXIME SODIUM | WOCKHARDT LIMITED (IN) | 2005-08-25 | — | — | WO | disclosed |
| WO-2005076694-A2 | IMPROVED PROCESS FOR THE PRODUCTION OF CEFOTAXIME SODIUM | WOCKHARDT LIMITED (IN) | 2005-08-25 | — | — | WO | disclosed |
| US-4388316-A | BACTERICIDES | ELI LILLY AND COMPANY (US) | 1983-06-14 | — | — | US | disclosed |
| US-4379787-A | ANTIBIOTICS | ELI LILLY AND COMPANY (US) | 1983-04-12 | — | — | US | disclosed |
| US-4379739-A | Electrolytic reduction of cephalosporin p-nitrobenzyl esters | ELI LILLY AND COMPANY (US) | 1983-04-12 | — | — | US | disclosed |
| EP-0074268-A2 | Improvements in or relating to thieno and furopyridinium-substituted cephalosporin derivatives | ELI LILLY AND COMPANY (US) | 1983-03-16 | — | — | EP | disclosed |
| EP-0060144-A2 | Cephalosporin antibiotics | ELI LILLY AND COMPANY (US) | 1982-09-15 | — | — | EP | disclosed |
| US-4336253-A | Cephalosporin antibiotics | ELI LILLY AND COMPANY (US) | 1982-06-22 | — | — | US | disclosed |
| US-4331666-A | BACTERICIDAL CEPHALOSPORIN ANTIBIOTICS | FARMITALIA CARLO ERBA S.P.A. (IT) | 1982-05-25 | — | — | US | disclosed |
| EP-0049118-A2 | Cephalosporin derivatives, their preparation and compositions containing them | SANKYO COMPANY LIMITED (JP) | 1982-04-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070004916-A1 | Process for the production of cefotaxime sodium | TALDO1, CEPT1, ADH1A | NR1I2 4562/4885MAPT 1454/4885PPARG 2995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.