Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 10/20 | 0.47 |
| ▸ | SCN7A | Q01118 | 3/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.32 |
| ▸ | SCN4A | P35499 | 1/20 | 0.32 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.32 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | CCR3 | P51677 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL19064935 | 1.00 | SCN9A (0.47) | SCN9ASCN7ASCN5AADRB2EPHX2 | |
| SCHEMBL17428303 | 0.98 | SCN9A (0.48) | SCN9ASCN7ASCN5AADRB2EPHX2 | |
| SCHEMBL17423024 | 0.98 | SCN9A (0.48) | SCN9ASCN7ASCN5AADRB2EPHX2 | |
| Trifluoroacetic Acid SCHEMBL19064795 | 0.91 | SCN9A (0.53) | SCN9ASCN7ASCN5AKCNH2 | |
| SCHEMBL19064757 | 0.88 | SCN9A (0.46) | SCN9ASCN7ASCN5AADRB2EPHX2 | |
| SCHEMBL17428683 | 0.88 | SCN9A (0.46) | SCN9ASCN7ASCN5AADRB2EPHX2 | |
| SCHEMBL17428435 | 0.88 | SCN9A (0.55) | SCN9ASCN7ASCN5AKCNH2 | |
| SCHEMBL19084006 | 0.87 | SCN9A (0.44) | SCN9ASCN7ASCN5AEPHX2 | |
| SCHEMBL19084009 | 0.87 | SCN9A (0.44) | SCN9ASCN7ASCN5AEPHX2 | |
| SCHEMBL21075343 | 0.85 | SCN9A (0.52) | SCN9ASCN7ASCN5AADRB2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | Genentech, Inc. (US) | 2017-05-17 | — | — | EP | disclosed |
| WO-2016007534-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2016-01-14 | — | — | WO | disclosed |