Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16771206 | 0.90 | SCN9A (0.53) | SCN9AADRB2SCN7ASCN5AEPHX2 | |
| SCHEMBL16771091 | 0.89 | SCN9A (0.56) | SCN9AADRB2SCN7ASCN5AEPHX2 | |
| Hydrochloric Acid SCHEMBL17061970 | 0.89 | SCN9A (0.52) | SCN9AADRB2SCN7ASCN5AEPHX2 | |
| SCHEMBL21075160 | 0.88 | SCN9A (0.47) | SCN9AADRB2GAAPLA2G1BPOLB | |
| SCHEMBL17423024 | 0.87 | SCN9A (0.48) | SCN9AADRB2GAASCN7ASCN5A | |
| SCHEMBL17428303 | 0.87 | SCN9A (0.48) | SCN9AADRB2GAASCN7ASCN5A | |
| SCHEMBL16771247 | 0.86 | SCN9A (0.50) | SCN9AADRB2SCN7ASCN5AEPHX2 | |
| SCHEMBL21075216 | 0.86 | SCN9A (0.51) | SCN9AADRB2GAAPLA2G1BPOLB | |
| Trifluoroacetic Acid SCHEMBL19064935 | 0.85 | SCN9A (0.47) | SCN9AADRB2GAASCN7ASCN5A | |
| Trifluoroacetic Acid SCHEMBL17423118 | 0.85 | SCN9A (0.47) | SCN9AADRB2GAASCN7ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-B1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH INC (US) | 2019-06-05 | — | — | EP | disclosed |