Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.65 |
| ▸ | GSPT1 | P15170 | 4/20 | 0.57 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.55 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.54 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL17420696 | 0.99 | CRBN (0.64) | CRBNGSPT1DDB1IKZF3IKZF2 | |
| SCHEMBL17432016 | 0.91 | CRBN (0.65) | CRBNGSPT1DDB1IKZF3IKZF2 | |
| SCHEMBL29480083 | 0.91 | CRBN (0.65) | CRBNGSPT1DDB1IKZF3IKZF2 | |
| SCHEMBL23240104 | 0.89 | CRBN (0.65) | CRBNGSPT1DDB1IKZF3IKZF2 | |
| SCHEMBL23239907 | 0.89 | CRBN (0.62) | CRBNGSPT1DDB1IKZF3IKZF2 | |
| SCHEMBL23683345 | 0.88 | CRBN (0.61) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL24501690 | 0.87 | CRBN (0.69) | CRBNGSPT1IKZF2 | |
| SCHEMBL19503721 | 0.87 | CRBN (0.69) | CRBNGSPT1IKZF2 | |
| SCHEMBL26088463 | 0.86 | CRBN (0.64) | CRBNGSPT1DDB1IKZF3IKZF2 | |
| SCHEMBL23240150 | 0.86 | CRBN (0.61) | CRBNGSPT1DDB1IKZF3IKZF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166937-A1 | ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF | Celgene Corporation (US) | 2017-05-17 | — | — | EP | disclosed |
| WO-2016007848-A1 | ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF | CELGENE CORPORATION (US) | 2016-01-14 | — | — | WO | disclosed |