Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 3/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.47 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.47 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.47 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.45 |
| ▸ | RBP4 | P02753 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17324736 | 0.87 | ROCK1 (0.47) | MAP2K4GSK3BPRKAB2PRKAG1PRKAA2 | |
| SCHEMBL7379535 | 0.85 | MAP2K4 (0.61) | MAP2K4GSK3BPRKAB2PRKAG1PRKAA2 | |
| SCHEMBL30443279 | 0.85 | MAP2K4 (0.61) | MAP2K4GSK3BPRKAB2PRKAG1PRKAA2 | |
| SCHEMBL15540985 | 0.83 | MAP2K4 (0.52) | MAP2K4GSK3BPRKAB2PRKAG1PRKAA2 | |
| SCHEMBL30609861 | 0.83 | MAP2K4 (0.65) | MAP2K4GSK3BPAK1NR4A2KDM4E | |
| SCHEMBL4791992 | 0.83 | MAP2K4 (0.65) | MAP2K4GSK3BPAK1NR4A2KDM4E | |
| SCHEMBL13302523 | 0.81 | PDPK1 (0.53) | GSK3BPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL30319390 | 0.81 | KMT2A (0.44) | GSK3BCHEK1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL26071341 | 0.81 | KMT2A (0.44) | GSK3BCHEK1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL15077318 | 0.80 | DYRK1A (0.61) | GSK3BPRKAB2PRKAG1PRKAA2PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016007837-A1 | CARBONYL LINKED BICYCLIC HETEROARYL ANTIBIOTIC TOLERANCE INHIBITORS | SPERO THERAPEUTICS, INC. (US) | 2016-01-14 | — | — | WO | disclosed |
| WO-2016007837-A1 | CARBONYL LINKED BICYCLIC HETEROARYL ANTIBIOTIC TOLERANCE INHIBITORS | SPERO THERAPEUTICS, INC. (US) | 2016-01-14 | — | — | WO | disclosed |