Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 3/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17423777 | 0.79 | LMNA (0.59) | KMT2AMEN1POLBMAPK1LTA4H | |
| SCHEMBL17423787 | 0.75 | MEN1 (0.59) | KMT2AMEN1POLBMAPK1KDM4E | |
| SCHEMBL5687538 | 0.74 | KDM4E (0.50) | KMT2AMEN1KDM4ELTA4HPTGS2 | |
| SCHEMBL17913570 | 0.73 | MEN1 (0.49) | KMT2AMEN1POLBMAPK1KDM4E | |
| SCHEMBL5101443 | 0.72 | MEN1 (0.47) | KMT2AMEN1POLBMAPK1MAOA | |
| SCHEMBL3875658 | 0.72 | MEN1 (0.47) | KMT2AMEN1POLBMAPK1KDM4E | |
| SCHEMBL31156719 | 0.72 | MEN1 (0.54) | KMT2AMEN1POLBMAPK1KDM4E | |
| SCHEMBL5113767 | 0.72 | MEN1 (0.50) | KMT2AMEN1POLBMAPK1LTA4H | |
| SCHEMBL13676215 | 0.71 | TRPV1 (0.45) | KMT2AMEN1POLBMAPK1KDM4E | |
| SCHEMBL17913477 | 0.71 | MEN1 (0.49) | KMT2AMEN1POLBMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016112088-A1 | ARYLOXYACETYLINDOLES AND ANALOGS AS ANTIBIOTIC TOLERANCE INHIBITORS | SPERO THERAPEUTICS, INC. (US) | 2016-07-14 | — | — | WO | disclosed |
| WO-2016007837-A1 | CARBONYL LINKED BICYCLIC HETEROARYL ANTIBIOTIC TOLERANCE INHIBITORS | SPERO THERAPEUTICS, INC. (US) | 2016-01-14 | — | — | WO | disclosed |
| WO-2016007837-A1 | CARBONYL LINKED BICYCLIC HETEROARYL ANTIBIOTIC TOLERANCE INHIBITORS | SPERO THERAPEUTICS, INC. (US) | 2016-01-14 | — | — | WO | disclosed |