Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 3/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ATF4 | P18848 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2738928 | 1.00 | MC4R (0.46) | MC4RRPS6KB1AKT1AURKBINCENP | |
| SCHEMBL683581 | 0.89 | MC4R (0.47) | MC4RALDH1A1USP2GPR139MEN1 | |
| SCHEMBL685484 | 0.89 | MC4R (0.47) | MC4RALDH1A1USP2GPR139MEN1 | |
| SCHEMBL12292609 | 0.88 | MC4R (0.42) | MC4RRPS6KB1AKT1AURKBINCENP | |
| SCHEMBL681336 | 0.87 | MC4R (0.48) | MC4RALDH1A1USP2GPR139MEN1 | |
| SCHEMBL681298 | 0.87 | MC4R (0.48) | MC4RALDH1A1USP2GPR139MEN1 | |
| SCHEMBL17424830 | 0.85 | KDM4E (0.45) | RPS6KB1AKT1AURKBINCENPALDH1A1 | |
| SCHEMBL2739268 | 0.84 | AKT1 (0.41) | RPS6KB1AKT1AURKBINCENPALDH1A1 | |
| SCHEMBL2739269 | 0.84 | AKT1 (0.41) | RPS6KB1AKT1AURKBINCENPALDH1A1 | |
| SCHEMBL2738568 | 0.83 | MC4R (0.41) | MC4RAKT1POLBTSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2966065-A2 | HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2016-01-13 | — | — | EP | disclosed |