Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL683453 | 0.88 | PAX8 (0.55) | KDM4ELMNAMAPTTP53MAPK1 | |
| SCHEMBL22622553 | 0.86 | PAX8 (0.46) | KDM4ELMNAMAPTTP53MAPK1 | |
| SCHEMBL681256 | 0.86 | LMNA (0.44) | KDM4ELMNAMAPTTP53MAPK1 | |
| SCHEMBL17424829 | 0.85 | MC4R (0.46) | KDM4EMAPTALDH1A1RPS6KB1AKT1 | |
| SCHEMBL2738928 | 0.85 | MC4R (0.46) | KDM4EMAPTALDH1A1RPS6KB1AKT1 | |
| SCHEMBL2739268 | 0.84 | AKT1 (0.41) | KDM4ELMNAALDH1A1RPS6KB1AKT1 | |
| SCHEMBL2739269 | 0.84 | AKT1 (0.41) | KDM4ELMNAALDH1A1RPS6KB1AKT1 | |
| SCHEMBL12292609 | 0.83 | MC4R (0.42) | RPS6KB1AKT1AURKBINCENPGPR139 | |
| SCHEMBL17424834 | 0.82 | ALDH1A1 (0.49) | KDM4ELMNAMAPTTP53MAPK1 | |
| SCHEMBL8223736 | 0.82 | ALDH1A1 (0.49) | KDM4ELMNAMAPTTP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2966065-A2 | HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2016-01-13 | — | — | EP | disclosed |