SCHEMBL17424962

SCHEMBL17424962

COc1cc(C(=O)N(NC(=O)c2ccc3c(c2C)OCCO3)C(C)(C)C)c(N=O)c(OC)c1C

nearest known ligand 0.45

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ABCB1 P08183 1/20 0.42
PLK1 P53350 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9100034 0.88 ABCB1 (0.43) ABCB1PLK1
SCHEMBL668808 0.85 ABCB1 (0.41) ABCB1
SCHEMBL668714 0.84 ABCB1 (0.55) ABCB1PLK1
SCHEMBL668088 0.80 ABCB1 (0.53) ABCB1PLK1
SCHEMBL668264 0.80 ABCB1 (0.51) ABCB1PLK1
SCHEMBL5057465 0.76 ABCB1 (0.48) ABCB1PLK1
SCHEMBL667668 0.76 ABCB1 (0.39) ABCB1
SCHEMBL5057404 0.76 ABCB1 (0.57) ABCB1
SCHEMBL668764 0.76 ABCB1 (0.57) ABCB1
SCHEMBL668148 0.74 ABCB1 (0.44) ABCB1PLK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2463269-B1 Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex INTREXON CORP (US) 2016-09-28 EP disclosed
EP-2460786-B1 Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex INTREXON CORP (US) 2016-01-13 EP disclosed