Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 20/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 20/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 20/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 20/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 17/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 17/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 17/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 17/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 17/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 17/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 17/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16302041 | 0.92 | ALOX15 (0.43) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL16302012 | 0.85 | HDAC1 (0.51) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL16302010 | 0.84 | HDAC6 (0.53) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL16302045 | 0.83 | HDAC1 (0.49) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL8011347 | 0.83 | HDAC1 (0.49) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL16302069 | 0.81 | HDAC6 (0.47) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL16581065 | 0.81 | HDAC6 (0.47) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL16302008 | 0.80 | HDAC1 (0.53) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL16302006 | 0.80 | HDAC6 (0.42) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL18371376 | 0.80 | HDAC6 (0.42) | HDAC3HDAC1HDAC2HDAC6HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2966078-A2 | Inhibitors of histone deacetylase | MethylGene Inc. (CA) | 2016-01-13 | — | — | EP | disclosed |