Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 8/20 | 0.47 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 3/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.31 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL144722 | 0.86 | BTK (0.49) | BTKPDCD1CD274JAK2P2RX7 | |
| SCHEMBL29709488 | 0.86 | BTK (0.49) | BTKPDCD1CD274JAK2P2RX7 | |
| SCHEMBL148493 | 0.78 | BTK (0.46) | BTKPDCD1CD274JAK2P2RX7 | |
| SCHEMBL147175 | 0.76 | BTK (0.45) | BTKPDCD1CD274JAK2 | |
| SCHEMBL123338 | 0.74 | BTK (0.46) | BTKPDCD1CD274JAK2ADAM17 | |
| SCHEMBL15284621 | 0.73 | BTK (0.42) | BTKPDCD1CD274JAK2MAP3K5 | |
| SCHEMBL123726 | 0.73 | BTK (0.52) | BTKPDCD1CD274JAK2P2RX7 | |
| SCHEMBL148927 | 0.72 | NPC1 (0.45) | BTKPDCD1CD274JAK2MAP3K5 | |
| SCHEMBL151946 | 0.70 | BTK (0.43) | BTKPDCD1CD274JAK2 | |
| SCHEMBL123774 | 0.68 | BTK (0.46) | BTKPDCD1CD274JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582668-B1 | CARBOLINE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-01-13 | — | — | EP | disclosed |