Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 8/20 | 0.49 |
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 8/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL144722 | 1.00 | BTK (0.49) | BTKJAK2PDCD1CD274IDO1 | |
| SCHEMBL148493 | 0.92 | BTK (0.46) | BTKJAK2PDCD1CD274IDO1 | |
| SCHEMBL147175 | 0.89 | BTK (0.45) | BTKJAK2PDCD1CD274 | |
| SCHEMBL123338 | 0.87 | BTK (0.46) | BTKJAK2PDCD1CD274ADAM17 | |
| SCHEMBL17425876 | 0.86 | BTK (0.47) | BTKJAK2PDCD1CD274P2RX7 | |
| SCHEMBL148927 | 0.85 | NPC1 (0.45) | BTKJAK2PDCD1CD274 | |
| SCHEMBL15284621 | 0.85 | BTK (0.42) | BTKJAK2PDCD1CD274 | |
| SCHEMBL151946 | 0.83 | BTK (0.43) | BTKJAK2PDCD1CD274 | |
| SCHEMBL123774 | 0.81 | BTK (0.46) | BTKJAK2PDCD1CD274 | |
| SCHEMBL148828 | 0.80 | JAK2 (0.49) | BTKJAK2PDCD1CD274IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4008328-A1 | PRIMARY CARBOXAMIDES AS BTK INHIBITORS | AbbVie Inc. (US) | 2022-06-08 | — | — | EP | disclosed |