Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 8/20 | 0.59 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 5/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21167810 | 0.88 | MET (0.45) | METKEAP1PIM1MERTK | |
| SCHEMBL16882499 | 0.88 | MET (0.64) | METKEAP1LRRK2PIM1NAMPT | |
| SCHEMBL21167627 | 0.87 | MET (0.48) | METKEAP1PIM1MERTKNAMPT | |
| SCHEMBL12489788 | 0.78 | MET (0.78) | MET | |
| SCHEMBL16882501 | 0.74 | MET (0.54) | METKEAP1NAMPT | |
| SCHEMBL12487441 | 0.74 | MET (1.00) | MET | |
| SCHEMBL21167805 | 0.73 | MET (0.54) | METKEAP1LRRK2NAMPT | |
| SCHEMBL23128008 | 0.73 | MET (0.46) | METLRRK2PIM1PIM3PIM2 | |
| SCHEMBL22475811 | 0.72 | MET (0.52) | MET | |
| SCHEMBL22475870 | 0.72 | MET (0.53) | METKEAP1LRRK2PIM1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511330-A1 | SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS | Hutchison Medipharma Limited (CN) | 2019-07-17 | — | — | EP | disclosed |
| EP-2966075-A1 | CERTAIN TRIAZOLOPYRIDINES, COMPOSITIONS THEREOF AND THEIR USE IN THE TREATMENT OF CANCER. | Hutchison Medipharma Limited (CN) | 2016-01-13 | — | — | EP | disclosed |