Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 17/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | NQO2 | P16083 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.41 |
| ▸ | WNT1 | P04628 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2177427 | 0.86 | MET (0.50) | METEGFRERBB2ERBB4DYRK1A | |
| SCHEMBL2361649 | 0.84 | MET (0.48) | METEGFRERBB2ERBB4DYRK1A | |
| SCHEMBL22475893 | 0.82 | MET (0.49) | METEGFRERBB2ERBB4DYRK1A | |
| SCHEMBL18418037 | 0.82 | MET (0.48) | METEGFRERBB2ERBB4DYRK1A | |
| SCHEMBL2176891 | 0.79 | MET (0.47) | METDYRK1ANQO2PDE3BPDE3A | |
| SCHEMBL29773408 | 0.78 | MET (0.48) | METEGFRERBB2ERBB4DYRK1A | |
| SCHEMBL2174986 | 0.78 | MET (0.48) | METEGFRERBB2ERBB4DYRK1A | |
| SCHEMBL2175368 | 0.76 | MET (0.45) | METEGFRERBB2ERBB4DYRK1A | |
| SCHEMBL29773380 | 0.75 | MET (0.43) | METDYRK1AWNT1 | |
| SCHEMBL12693353 | 0.75 | MET (0.43) | METDYRK1AWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2966075-A1 | CERTAIN TRIAZOLOPYRIDINES, COMPOSITIONS THEREOF AND THEIR USE IN THE TREATMENT OF CANCER. | Hutchison Medipharma Limited (CN) | 2016-01-13 | — | — | EP | disclosed |