SCHEMBL1743030

SCHEMBL1743030

CC(=O)Nc1cccc(-c2cnc(N3CCN(C(C)C)CC3)c(C)c2)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP11B2 P19099 1/20 0.49
CHEK1 O14757 2/20 0.47
FGFR1 P11362 1/20 0.47
NEK2 P51955 1/20 0.47
MAPK15 Q8TD08 1/20 0.47
FYN P06241 3/20 0.45
USP7 Q93009 1/20 0.45
MAP4K1 Q92918 1/20 0.44
CHEK2 O96017 1/20 0.44
AAK1 Q2M2I8 2/20 0.43
NTRK1 P04629 1/20 0.42
NPC1 O15118 1/20 0.42
TP53 P04637 1/20 0.42
STAT1 P42224 1/20 0.42
RAB9A P51151 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
PRMT5 O14744 1/20 0.42
WDR77 Q9BQA1 1/20 0.42
PIP4K2A P48426 1/20 0.41
PIP4K2B P78356 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1744142 0.88 HTT (0.42) SMN1; SMN2PTPN11OGADYRK1ADYRK1B
SCHEMBL1742801 0.83 PRKD1 (0.45) FYNNPC1TP53STAT1RAB9A
SCHEMBL1744319 0.82 LDHA (0.46) CYP11B2
SCHEMBL1744088 0.80 PIK3C3 (0.46) CHEK1FGFR1NEK2MAPK15FYN
SCHEMBL1742440 0.79 CYP3A4 (0.44) FYNMAP4K1SMN1; SMN2CYP3A4
SCHEMBL12159871 0.78 AOC3 (0.38) CYP11B2SMN1; SMN2
SCHEMBL1742941 0.77 NPC1 (0.42) NPC1TP53RAB9ASMN1; SMN2PRKD1
SCHEMBL1744351 0.76 CHEK1 (0.46) CHEK1FYNOGA
SCHEMBL1744154 0.74 NPC1 (0.61) NPC1TP53RAB9A
SCHEMBL1742557 0.73 TRPV1 (0.44) NPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12478615-B2 Prolyl hydroxylase inhibitors and methods of use AKEBIA THERAPEUTICS, INC. (US) 2025-11-25 US disclosed
US-20240358691-A1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE WARNER CHILCOTT COMPANY, LLC (PR) 2024-10-31 US disclosed
US-11883386-B2 Prolyl hydroxylase inhibitors and methods of use AKEBIA THERAPEUTICS, INC. (US) 2024-01-30 US disclosed
US-20230201178-A1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE KREOS CAPITAL VII (UK) LIMITED (GB) 2023-06-29 US disclosed
EP-4095127-A1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE Akebia Therapeutics Inc. (US) 2022-11-30 EP disclosed
US-11426393-B2 Prolyl hydroxylase inhibitors and methods of use AKEBIA THERAPEUTICS, INC. (US) 2022-08-30 US disclosed
EP-3357911-B1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE AKEBIA THERAPEUTICS INC (US) 2022-05-11 EP disclosed
US-20210137901-A1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE KREOS CAPITAL VII (UK) LIMITED (GB) 2021-05-13 US disclosed
US-10729681-B2 Prolyl hydroxylase inhibitors and methods of use AKEBIA THERAPEUTICS, INC. (US) 2020-08-04 US disclosed
US-20190192494-A1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE KREOS CAPITAL VII (UK) LIMITED (GB) 2019-06-27 US disclosed
US-20090312309-A1 Novel Medicaments HIGH POINT PHARMACEUTICALS, LLC (US) 2009-12-17 US disclosed
US-20090312309-A1 Novel Medicaments HIGH POINT PHARMACEUTICALS, LLC (US) 2009-12-17 US disclosed
US-20090312309-A1 Novel Medicaments HIGH POINT PHARMACEUTICALS, LLC (US) 2009-12-17 US disclosed
EP-2044005-A2 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE The Procter and Gamble Company (US) 2009-04-08 EP disclosed
CN-101218206-A Histamine H3 receptor antagonists NOVO NORDISK AS (DK) 2008-07-09 CN disclosed
EP-1902028-A2 HISTAMINE H3 RECEPTOR ANTAGONISTS Novo Nordisk A/S (DK) 2008-03-26 EP disclosed
WO-2008002576-A2 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE THE PROCTER & GAMBLE COMPANY (US) 2008-01-03 WO disclosed
US-20070299086-A1 Prolyl hydroxylase inhibitors and methods of use THE PROCTER & GAMBLE COMPANY (US) 2007-12-27 US disclosed
WO-2007003604-A2 HISTS1MINE H3 RECEPTOR ANTAGONISTS NOVO NORDISK A/S (DK) 2007-01-11 WO disclosed
WO-2007003604-A2 HISTS1MINE H3 RECEPTOR ANTAGONISTS NOVO NORDISK A/S (DK) 2007-01-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11426393-B2 Prolyl hydroxylase inhibitors and methods of use HIF1AN, EGLN3, HIF1A CYP11B2 1571/4885CHEK1 3883/4885FGFR1 2524/4885
US-11883386-B2 Prolyl hydroxylase inhibitors and methods of use HIF1AN, EGLN3, HIF1A CYP11B2 1571/4885CHEK1 3883/4885FGFR1 2524/4885
US-20240358691-A1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE HIF1AN, EGLN3, EGLN2 CYP11B2 1532/4885CHEK1 4116/4885FGFR1 2668/4885
US-20190192494-A1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE HIF1AN, EGLN3, HIF1A CYP11B2 1571/4885CHEK1 3883/4885FGFR1 2524/4885
US-12478615-B2 Prolyl hydroxylase inhibitors and methods of use HIF1AN, EGLN3, HIF1A CYP11B2 1571/4885CHEK1 3883/4885FGFR1 2524/4885
US-20210137901-A1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE HIF1AN, EGLN3, HIF1A CYP11B2 1571/4885CHEK1 3883/4885FGFR1 2524/4885
US-20090312309-A1 Novel Medicaments HRH3, HRH4, HRH1 CYP11B2 864/4885CHEK1 2808/4885FGFR1 2111/4885
US-20230201178-A1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE HIF1AN, EGLN3, HIF1A CYP11B2 1571/4885CHEK1 3883/4885FGFR1 2524/4885
US-20070299086-A1 Prolyl hydroxylase inhibitors and methods of use HIF1AN, EGLN3, HIF1A CYP11B2 1571/4885CHEK1 3883/4885FGFR1 2524/4885
US-10729681-B2 Prolyl hydroxylase inhibitors and methods of use HIF1AN, EGLN3, HIF1A CYP11B2 1571/4885CHEK1 3883/4885FGFR1 2524/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.