Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 19/20 | 1.00 |
| ▸ | PDGFRB | P09619 | 17/20 | 1.00 |
| ▸ | KDR | P35968 | 17/20 | 1.00 |
| ▸ | FLT1 | P17948 | 5/20 | 1.00 |
| ▸ | LCK | P06239 | 2/20 | 0.73 |
| ▸ | PLK4 | O00444 | 1/20 | 0.73 |
| ▸ | STK25 | O00506 | 1/20 | 0.73 |
| ▸ | CIT | O14578 | 1/20 | 0.73 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.73 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.73 |
| ▸ | GAK | O14976 | 1/20 | 0.73 |
| ▸ | CHUK | O15111 | 1/20 | 0.73 |
| ▸ | MUSK | O15146 | 1/20 | 0.73 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.73 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.73 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.73 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.73 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.73 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.73 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3381227 | 0.92 | FGFR1 (0.85) | FGFR1PDGFRBKDRFLT1 | |
| SCHEMBL14795687 | 0.92 | FGFR1 (0.84) | FGFR1PDGFRBKDRFLT1LCK | |
| SCHEMBL3381059 | 0.90 | FGFR1 (1.00) | FGFR1PDGFRBKDRFLT1LCK | |
| SCHEMBL3381351 | 0.89 | FGFR1 (0.81) | FGFR1PDGFRBKDRFLT1LCK | |
| SCHEMBL14795663 | 0.89 | FGFR1 (1.00) | FGFR1PDGFRBKDRFLT1LCK | |
| SCHEMBL15910869 | 0.89 | FGFR1 (0.81) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL3380086 | 0.89 | FGFR1 (0.81) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL3384403 | 0.89 | FGFR1 (1.00) | FGFR1PDGFRBKDRFLT1CHEK1 | |
| SCHEMBL3379764 | 0.89 | FGFR1 (0.79) | FGFR1PDGFRBKDRFLT1 | |
| SCHEMBL3381338 | 0.89 | FGFR1 (0.86) | FGFR1PDGFRBKDRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11230589-B2 | Fusion molecules and uses thereof | FOUNDATION MEDICINE, INC. (US) | 2022-01-25 | — | — | US | disclosed |
| US-20160009785-A1 | NOVEL FUSION MOLECULES AND USES THEREOF | FOUNDATION MEDICINE, INC. | 2016-01-14 | — | — | US | disclosed |
| US-20160009785-A1 | NOVEL FUSION MOLECULES AND USES THEREOF | FOUNDATION MEDICINE, INC. | 2016-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11230589-B2 | Fusion molecules and uses thereof | RPS27A, CD2BP2, FGB | FGFR1 933/4885PDGFRB 234/4885KDR 1552/4885 |
| US-20160009785-A1 | NOVEL FUSION MOLECULES AND USES THEREOF | RPS27A, CD2BP2, FGB | FGFR1 849/4885PDGFRB 254/4885KDR 1464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.