Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARK3 | P27448 | 5/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SGK1 | O00141 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1743475 | 0.82 | MARK3 (0.41) | MARK3USP2KMT2ANPC1RAB9A | |
| SCHEMBL1692047 | 0.79 | MARK3 (0.41) | MARK3USP2KMT2ANPC1RAB9A | |
| SCHEMBL1743459 | 0.79 | MARK3 (0.63) | MARK3SGK1CHEK1IKBKBMAPK13 | |
| SCHEMBL10066134 | 0.75 | USP2 (0.50) | MARK3USP2KMT2ANPC1RAB9A | |
| SCHEMBL15187437 | 0.72 | USP2 (0.42) | MARK3USP2KMT2ANPC1RAB9A | |
| SCHEMBL1743478 | 0.69 | MARK3 (0.38) | MARK3KMT2ASGK1CHEK1IKBKB | |
| SCHEMBL15168469 | 0.69 | USP2 (0.42) | MARK3USP2KMT2ANPC1RAB9A | |
| SCHEMBL1691638 | 0.66 | MARK3 (0.38) | MARK3SGK1CHEK1IKBKBMAPK13 | |
| SCHEMBL3710952 | 0.66 | MARK3 (0.57) | MARK3SGK1CHEK1IKBKBMAPK13 | |
| SCHEMBL15187447 | 0.66 | MARK3 (0.49) | MARK3SGK1CHEK1IKBKBMAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387315-A1 | IMIDAZO[1,2-a]PYRIDINES AND IMIDAZO[1,2-b]PYRIDAZINES AS MARK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2011-11-23 | — | — | EP | disclosed |
| WO-2010083145-A1 | IMIDAZO[1,2-a]PYRIDINES AND IMIDAZO[1,2-b]PYRIDAZINES AS MARK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-07-22 | — | — | WO | disclosed |