Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 15/20 | 0.39 |
| ▸ | HTR2B | P41595 | 10/20 | 0.37 |
| ▸ | HTR2A | P28223 | 9/20 | 0.37 |
| ▸ | BRD4 | O60885 | 5/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.36 |
| ▸ | HTR6 | P50406 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016129 | 0.89 | HTR2C (0.40) | HTR2CHTR2BHTR2ABRD4CREBBP | |
| SCHEMBL2017913 | 0.88 | HTR2C (0.41) | HTR2CHTR2BHTR2ABRD4CREBBP | |
| SCHEMBL2017394 | 0.88 | HTR2C (0.41) | HTR2CHTR2BHTR2ABRD4CREBBP | |
| SCHEMBL692434 | 0.82 | BRD4 (0.55) | HTR2CHTR2BHTR2ABRD4CREBBP | |
| SCHEMBL2014277 | 0.82 | BRD4 (0.55) | HTR2CHTR2BHTR2ABRD4CREBBP | |
| SCHEMBL2019541 | 0.82 | HTR2C (0.42) | HTR2CHTR2BHTR2AHTR6 | |
| SCHEMBL2017396 | 0.80 | HTR2C (0.41) | HTR2CHTR2BHTR2ABRD4CREBBP | |
| SCHEMBL2556591 | 0.80 | HTR2C (0.41) | HTR2CHTR2BHTR2ABRD4CREBBP | |
| SCHEMBL693191 | 0.78 | HTR2C (0.58) | HTR2CHTR2BHTR2AHTR6 | |
| SCHEMBL691878 | 0.78 | HTR2C (0.58) | HTR2CHTR2BHTR2AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2522671-B1 | Modulators of 5-HT receptors and methods of use thereof | ABBVIE INC (US) | 2016-01-20 | — | — | EP | disclosed |