⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2695239 | 0.81 | — | — | |
| SCHEMBL2695237 | 0.81 | — | — | |
| SCHEMBL18244429 | 0.77 | CNR2 (0.30) | — | |
| SCHEMBL16822017 | 0.77 | CNR2 (0.30) | — | |
| SCHEMBL1061762 | 0.76 | TRPM8 (0.35) | — | |
| SCHEMBL1543231 | 0.76 | TRPM8 (0.35) | — | |
| SCHEMBL1543480 | 0.76 | TRPM8 (0.35) | — | |
| SCHEMBL1543478 | 0.76 | TRPM8 (0.35) | — | |
| SCHEMBL1543230 | 0.76 | TRPM8 (0.35) | — | |
| SCHEMBL527479 | 0.73 | DPP4 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9908895-B2 | Tricyclic fused thiophene derivatives as JAK inhibitors | INCYTE CORPORATION (US) | 2018-03-06 | — | — | US | disclosed |
| US-20160024109-A1 | TRICYCLIC FUSED THIOPHENE DERIVATIVES AS JAK INHIBITORS | INCYTE HOLDINGS CORPORATION | 2016-01-28 | — | — | US | disclosed |
| US-20160015695-A1 | TRICYCLIC FUSED THIOPHENE DERIVATIVES AS JAK INHIBITORS | INCYTE CORPORATION | 2016-01-21 | — | — | US | disclosed |