Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD63 | P08962 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | CD38 | P28907 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16851815 | 0.75 | CD63 (0.38) | CD63SYKJAK2TBK1KDM4C | |
| SCHEMBL16851817 | 0.72 | SYK (0.56) | CD63SYKJAK2 | |
| SCHEMBL30029737 | 0.72 | ALDH1A1 (0.40) | — | |
| SCHEMBL16851816 | 0.72 | ALDH1A1 (0.40) | — | |
| SCHEMBL17583490 | 0.65 | KDM4C (0.40) | KDM4C | |
| SCHEMBL30202722 | 0.65 | KDM4C (0.33) | CD63SYKKDM4C | |
| SCHEMBL30310838 | 0.63 | MAPT (0.41) | KDM4C | |
| SCHEMBL1345450 | 0.62 | KDM4C (0.49) | KDM4C | |
| SCHEMBL15508886 | 0.61 | KDM4C (0.43) | KDM4C | |
| SCHEMBL13420092 | 0.61 | KDM4C (0.43) | KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3169329-A1 | SYK INHIBITORS | Gilead Sciences, Inc. (US) | 2017-05-24 | — | — | EP | disclosed |
| WO-2016010809-A1 | SYK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2016-01-21 | — | — | WO | disclosed |