Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16773339 | 1.00 | KDM4E (0.45) | KDM4ECYP1A2CYP3A4NPC1CYP2D6 | |
| SCHEMBL6322494 | 0.85 | KDM4E (0.42) | KDM4ECYP1A2CYP3A4NPC1CYP2D6 | |
| SCHEMBL6322485 | 0.85 | KDM4E (0.42) | KDM4ECYP1A2CYP3A4NPC1CYP2D6 | |
| SCHEMBL6493624 | 0.83 | BACE1 (0.36) | KDM4ECYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6493621 | 0.83 | BACE1 (0.36) | KDM4ECYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL21960080 | 0.82 | PPARA (0.41) | KDM4ECYP1A2CYP3A4NPC1CYP2D6 | |
| SCHEMBL7395928 | 0.82 | IDO1 (0.55) | — | |
| SCHEMBL29566039 | 0.82 | IDO1 (0.55) | — | |
| SCHEMBL7395933 | 0.82 | IDO1 (0.55) | — | |
| SCHEMBL22382771 | 0.77 | KDM4E (0.50) | KDM4ECYP1A2CYP3A4NPC1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2859002-B1 | SILICON-BASED CROSS COUPLING AGENTS AND METHODS OF THEIR USE | UNIV PENNSYLVANIA (US) | 2020-12-30 | — | — | EP | disclosed |
| US-9850261-B2 | Silicon-based cross coupling agents and methods of their use | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2017-12-26 | — | — | US | disclosed |
| US-20170210766-A1 | SILICON-BASED CROSS COUPLING AGENTS AND METHODS OF THEIR USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-07-27 | — | — | US | disclosed |
| US-9499660-B2 | Silicon-based cross coupling agents and methods of their use | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-11-22 | — | — | US | disclosed |
| WO-2016011231-A1 | SILICON-BASED CROSS COUPLING AGENTS AND METHODS OF THEIR USE | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170210766-A1 | SILICON-BASED CROSS COUPLING AGENTS AND METHODS OF THEIR USE | RAD51, CA1, DCLRE1A | KDM4E 4034/4885CYP1A2 4580/4885CYP3A4 4797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.