Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.30 |
| ▸ | USP5 | P45974 | 1/20 | 0.30 |
| ▸ | USP9X | Q93008 | 1/20 | 0.30 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.30 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17440496 | 0.80 | ALDH1A1 (0.40) | IRAK4TP53BP1ALDH1A1HPGD | |
| SCHEMBL17440635 | 0.80 | IRAK4 (0.33) | IRAK4 | |
| SCHEMBL17440865 | 0.78 | IRAK4 (0.37) | IRAK4 | |
| SCHEMBL28439621 | 0.76 | IRAK4 (0.43) | IRAK4CA2 | |
| SCHEMBL17440700 | 0.72 | IRAK4 (0.35) | IRAK4ALDH1A1HPGDUCHL1USP5 | |
| SCHEMBL10005123 | 0.69 | IRAK4 (0.40) | IRAK4 | |
| SCHEMBL17440719 | 0.68 | IRAK4 (0.30) | IRAK4 | |
| SCHEMBL23354281 | 0.68 | MEN1 (0.40) | ALDH1A1MEN1GAAKMT2A | |
| SCHEMBL4839737 | 0.65 | IRAK4 (0.36) | IRAK4ALDH1A1KMT2ACA2UCHL1 | |
| SCHEMBL4839728 | 0.65 | IRAK4 (0.36) | IRAK4ALDH1A1KMT2ACA2UCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016011390-A1 | IRAK4 INHIBITING AGENTS | BIOGEN MA INC. (US) | 2016-01-21 | — | — | WO | disclosed |