Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | EZH2 | Q15910 | 9/20 | 0.40 |
| ▸ | EZH1 | Q92800 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1742424 | 0.88 | SMO (0.52) | SMOTLR9TLR8TLR7EZH2 | |
| SCHEMBL1742928 | 0.86 | TLR9 (0.49) | SMOTLR9TLR8TLR7 | |
| SCHEMBL1743026 | 0.78 | SMO (0.51) | SMOTLR9TLR8TLR7EZH2 | |
| SCHEMBL23291895 | 0.78 | PLK1 (0.57) | CTSLCTSBCTSSCTSKLMNA | |
| SCHEMBL12159826 | 0.78 | HRH3 (0.43) | SMOTLR9TLR8TLR7EZH2 | |
| SCHEMBL1743218 | 0.77 | HRH3 (0.44) | SMOTLR9TLR8TLR7EZH2 | |
| SCHEMBL1743006 | 0.77 | ADAMTS4 (0.43) | SMOACACB | |
| SCHEMBL1742562 | 0.76 | SMO (0.46) | SMOMAPT | |
| SCHEMBL1742648 | 0.76 | HPGD (0.44) | SMOTLR9TLR8TLR7EZH2 | |
| Hydrochloric Acid SCHEMBL3045179 | 0.75 | SMO (0.45) | SMOMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2386554-A1 | Compounds active at the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2011-11-16 | — | — | EP | disclosed |