ADAMTS4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL689670	0.80	16/20
SCHEMBL689671	0.80	16/20
SCHEMBL689561	0.80	10/20
SCHEMBL689562	0.80	10/20
SCHEMBL688448	0.58	8/20
SCHEMBL688449	0.58	8/20
SCHEMBL847291	0.35	6/20
Hydrochloric Acid (SCHEMBL688755)	0.60	5/20
SCHEMBL689439	0.53	5/20
SCHEMBL689440	0.53	5/20
SCHEMBL569306	0.40	5/20
SCHEMBL255126	0.51	4/20
SCHEMBL568976	0.49	4/20
SCHEMBL569735	0.49	4/20
SCHEMBL849537	0.34	4/20
SCHEMBL849149	0.33	4/20
SCHEMBL710361	0.32	4/20
SCHEMBL848480	0.32	4/20
SCHEMBL849236	0.32	4/20
SCHEMBL851294	0.31	4/20

Clinical trials — most relevant to ADAMTS4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Prophylactic Plasma Infusion Therapy for Congenital Thrombotic Thrombocytopenic Purpura	PHASE4	WITHDRAWN
PRP in ACLR to Prevent PTOA	PHASE3	RECRUITING
Aspirin for Prophylaxis of TTP	PHASE2/PHASE3	NOT_YET_RECRUITING
The Use of Rituximab in Acute Thrombotic Thrombocytopenic Purpura (TTP)	PHASE2	COMPLETED
Sputum Matrix Metalloproteinases (MMP) mRNA and Montelukast	PHASE2	COMPLETED
Synvisc to Treat Osteoarthritis of the Temporomandibular Joint	PHASE2	COMPLETED
Phase 1 Dose Escalation, Single Dose Study to Assess Safety and Pharmacokinetics of BAX930 in Hereditary Thrombotic Thrombocytopenic Purpura (TTP)	PHASE1	COMPLETED
The Role of Matrix Metalloproteinases (MMPs) in Orthodontic Tooth Movement	PHASE1	COMPLETED
ADAMTS-13 LEVEL AS PREDICTIVE BIOMARKER FOR DEVELOPMENT OF PORTAL VEIN THROMBOSIS IN LIVER CIRRHOSIS (ADAPTHRO)	nan	UNKNOWN
Exercise-related Irisin on Inflammation and Pain	nan	UNKNOWN
Extracellular Matrix Remodeling of the Umbilical Cord and Placenta in Preeclampsia	nan	UNKNOWN
Role of A Disintegrin and Metalloproteinase (ADAM) in Epithelial Dysfunction	nan	COMPLETED
Role and Expression of MXRA5 in Placental Connective Tissue Remodelling in Preeclampsia	nan	UNKNOWN
Genotype and Phenotype Correlation in Hereditary Thrombotic Thrombocytopenic Purpura (Upshaw-Schulman Syndrome)	nan	RECRUITING
Evaluation of Different Serum Cartilage Biomarkers in the Acute Response to Walking and Cycling in Healthy Male Subjects	nan	AVAILABLE
Improvement of Immunologic and Molecular Techniques for the Diagnosis and Follow-up of Patients With Thrombotic Thrombocytopenic Purpura	nan	ACTIVE_NOT_RECRUITING
Prognostic Indices of Atheromatosis Severity and Coronary Artery Bypass Surgery Outcomes for Patients With Coronary Artery Disease	nan	ACTIVE_NOT_RECRUITING
ADAMTS13 in Thrombotic Thrombocytopenic Purpura	nan	COMPLETED
A Retrospective, Observational Study on the Response to Caplacizumab Treatment in aTTP Patients: the Italian Experience (ROSCAPLI)	nan	UNKNOWN
COL4A1COL4A2: Study of Pathological Conditions Involving Multiple Organs Caused by Mutations in the COL4A1 and COL4A2 Genes	nan	RECRUITING
Apoptotic Changes in Gingiva Caused by Smoking	nan	COMPLETED
Re-evaluation of Some Old Rheumatoid Arthritis Therapy: A Randomized Controlled Trial	nan	COMPLETED
Screening of TMA Patients für ADAMTS13 Activity (Adamscreen)	nan	UNKNOWN
Peri-implantitis and MMP-8	nan	COMPLETED
Detection of Cancer-Specific Active Proteases in Blood Via Fluorescence	nan	WITHDRAWN
Matrix Metalloproteinases After Surgery and/or Radiofrequency Ablation in Patients With Liver Metastases From Colorectal Cancer	nan	COMPLETED
Matrix Metalloproteinases 7 and 9 in Rheumatoid Arthritis Patients With Interstitial Lung Disease	nan	NOT_YET_RECRUITING
LRP1 and Colon Cancer	nan	UNKNOWN
Plasma Levels of Matrix Metalloproteinases (MMPs) and Degree of DNA Fragmentation in Pseudoexfoliation (PEX) Glaucoma	nan	COMPLETED
Role of Extracellular Matrix in the Development of Airway Remodeling in Asthma	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a ADAMTS4 binder may also engage these)

Protein	Name	Similarity
Q8BNJ2	—	1.000	Q8BNJ2 →
Q9TT93	—	1.000	Q9TT93 →
Q5RFQ8	—	1.000	Q5RFQ8 →
Q13444	—	0.993	Q13444 →
ADAM8	Disintegrin and metalloproteinase domain-containing protein 8	0.988	landscape →
ADAMTS7	A disintegrin and metalloproteinase with thrombospondin motifs 7	0.988	landscape →
P57110	—	0.987	P57110 →
Q8TE58	—	0.984	Q8TE58 →
Q9QYV0	—	0.984	Q9QYV0 →
O88839	—	0.983	O88839 →
Q9H324	—	0.982	Q9H324 →
O35674	—	0.981	O35674 →
ADAM12	Disintegrin and metalloproteinase domain-containing protein 12	0.981	landscape →
Q9ESP7	—	0.981	Q9ESP7 →
P58459	—	0.981	P58459 →
Q8WXS8	—	0.980	Q8WXS8 →
Q9R0S3	—	0.980	Q9R0S3 →
P59384	—	0.979	P59384 →
Q9NS98	—	0.978	Q9NS98 →
Q9UP79	—	0.978	Q9UP79 →
Q05910	—	0.977	Q05910 →
O95450	—	0.977	O95450 →
A8T658	—	0.977	A8T658 →
Q9C0C4	—	0.977	Q9C0C4 →
A8T688	—	0.976	A8T688 →
Q61824	—	0.976	Q61824 →
ADAMTS1	A disintegrin and metalloproteinase with thrombospondin motifs 1	0.976	landscape →
Q9H013	—	0.976	Q9H013 →
P60882	—	0.976	P60882 →
Q8WN18	—	0.976	Q8WN18 →