Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.35 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2882448 | 0.80 | — | — | |
| SCHEMBL5799756 | 0.78 | EGFR (0.33) | — | |
| SCHEMBL3401752 | 0.78 | TSHR (0.51) | PDE3BPDE3ATSHRALDH1A1L3MBTL1 | |
| SCHEMBL29354025 | 0.78 | TSHR (0.51) | PDE3BPDE3ATSHRALDH1A1L3MBTL1 | |
| SCHEMBL10130347 | 0.72 | TSHR (0.58) | PDE3BPDE3AGRM4TSHRALDH1A1 | |
| SCHEMBL10129864 | 0.72 | TSHR (0.58) | PDE3BPDE3AGRM4TSHRALDH1A1 | |
| SCHEMBL10130351 | 0.72 | TSHR (0.58) | PDE3BPDE3AGRM4TSHRALDH1A1 | |
| SCHEMBL10129667 | 0.71 | PDE3B (0.50) | PDE3BPDE3AGRM4TSHRALDH1A1 | |
| SCHEMBL21475872 | 0.71 | PDE3A (0.50) | PDE3BPDE3AGRM4TSHRALDH1A1 | |
| SCHEMBL10129678 | 0.71 | PDE3B (0.50) | PDE3BPDE3AGRM4TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2385939-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2011-11-16 | — | — | EP | disclosed |
| US-8041551-B1 | Algorithm and architecture for multi-argument associative operations that minimizes the number of components using a latency of the components | THE MATHWORKS, INC. (US) | 2011-10-18 | — | — | US | disclosed |
| WO-2010072597-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-07-01 | — | — | WO | disclosed |