Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 13/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 13/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GPR183 | P32249 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17444034 | 1.00 | OPRM1 (0.50) | OPRM1OPRL1POLBMEN1KMT2A | |
| SCHEMBL19137915 | 1.00 | OPRM1 (0.50) | OPRM1OPRL1POLBMEN1KMT2A | |
| SCHEMBL17443863 | 0.86 | OPRM1 (0.44) | OPRM1OPRL1POLBMEN1KMT2A | |
| SCHEMBL17443865 | 0.86 | OPRM1 (0.44) | OPRM1OPRL1POLBMEN1KMT2A | |
| SCHEMBL17444421 | 0.86 | OPRM1 (0.44) | OPRM1OPRL1POLBMEN1KMT2A | |
| SCHEMBL17444086 | 0.85 | OPRM1 (0.63) | OPRM1OPRL1POLBMEN1KMT2A | |
| SCHEMBL19137901 | 0.85 | OPRM1 (0.63) | OPRM1OPRL1POLBMEN1KMT2A | |
| SCHEMBL17444085 | 0.85 | OPRM1 (0.63) | OPRM1OPRL1POLBMEN1KMT2A | |
| SCHEMBL17444255 | 0.84 | OPRM1 (0.45) | OPRM1OPRL1POLBMEN1KMT2A | |
| SCHEMBL17444258 | 0.84 | OPRM1 (0.45) | OPRM1OPRL1POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3169666-A1 | SUBSTITUTED AZASPIRO(4.5)DECANE DERIVATIVES | Grünenthal GmbH (DE) | 2017-05-24 | — | — | EP | disclosed |
| WO-2016008582-A1 | SUBSTITUTED AZASPIRO(4.5)DECANE DERIVATIVES | Grünenthal GmbH (DE) | 2016-01-21 | — | — | WO | disclosed |