Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17444474 | 0.88 | L3MBTL1 (0.43) | L3MBTL1TSHRALDH1A1POLBHTT | |
| SCHEMBL17444470 | 0.88 | TSHR (0.45) | L3MBTL1TSHRALDH1A1POLBHTT | |
| SCHEMBL31465706 | 0.84 | TSHR (0.45) | L3MBTL1TSHRALDH1A1POLBHTT | |
| SCHEMBL398799 | 0.82 | USP2 (0.43) | TSHRSMN1; SMN2KDM4E | |
| SCHEMBL7055664 | 0.82 | CYP2C19 (0.37) | CYP2C19 | |
| SCHEMBL21806880 | 0.82 | MEN1 (0.52) | ALDH1A1HTTSMN1; SMN2KMT2ACYP2C19 | |
| SCHEMBL5767027 | 0.78 | CYP4F2 (0.39) | L3MBTL1ALDH1A1POLBSMN1; SMN2KMT2A | |
| SCHEMBL17444469 | 0.75 | TSHR (0.45) | L3MBTL1TSHRALDH1A1POLBHTT | |
| SCHEMBL30182246 | 0.74 | TSHR (0.50) | L3MBTL1TSHRALDH1A1POLBHTT | |
| SCHEMBL20608129 | 0.73 | CYP4F2 (0.43) | L3MBTL1ALDH1A1POLBSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016008064-A1 | INHIBITORS OF RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2016-01-21 | — | — | WO | disclosed |