SCHEMBL1744688

SCHEMBL1744688

NC(=O)N1c2ccccc2CCc2ccccc21

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.62
MEN1 O00255 3/20 0.62
KMT2A Q03164 3/20 0.62
KDM4E B2RXH2 2/20 0.62
CYP3A4 P08684 2/20 0.62
MAPT P10636 2/20 0.62
PABPC1 P11940 1/20 0.62
BLM P54132 1/20 0.62
NPC1 O15118 1/20 0.59
MITF O75030 1/20 0.59
RAB9A P51151 1/20 0.59
LMNA P02545 2/20 0.57
TSHR P16473 1/20 0.57
MAPK1 P28482 1/20 0.57
SCN4A P35499 1/20 0.57
SCN5A Q14524 1/20 0.57
SCN9A Q15858 1/20 0.57
BCHE P06276 1/20 0.55
ACHE P22303 1/20 0.55
HSD17B3 P37058 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31182096 1.00 ALDH1A1 (0.62) ALDH1A1MEN1KMT2AKDM4ECYP3A4
SCHEMBL3296716 0.82 TSHR (0.71) ALDH1A1MEN1KMT2AKDM4ECYP3A4
SCHEMBL11111811 0.82 KDM4E (0.47) ALDH1A1MEN1KMT2AKDM4ECYP3A4
SCHEMBL11117755 0.81 KDM4E (0.47) ALDH1A1MEN1KMT2AKDM4ECYP3A4
SCHEMBL4702616 0.79 ALDH1A1 (0.50) ALDH1A1MEN1KMT2AKDM4ECYP3A4
SCHEMBL11548268 0.79 KDM4E (0.67) ALDH1A1MEN1KMT2AKDM4ENPC1
SCHEMBL4221958 0.79 NPC1 (0.65) ALDH1A1MEN1KMT2AKDM4ECYP3A4
SCHEMBL11641398 0.79 MEN1 (0.50) ALDH1A1MEN1KMT2AKDM4ECYP3A4
SCHEMBL31182095 0.79 KDM4E (0.67) ALDH1A1MEN1KMT2AKDM4ENPC1
SCHEMBL8257409 0.79 NPC1 (0.69) ALDH1A1MEN1KMT2AKDM4ECYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111285805-A Preparation method of oxcarbazepine 重庆圣华曦药业股份有限公司 2020-06-16 CN claimed
EP-0108715-A1 Dibenzazepine carboxamides CIBA-GEIGY AG (CH) 1984-05-16 EP claimed
JP-7061930-A None JP disclosed
CN-118878463-A Method for synthesizing oxcarbazepine or intermediate thereof 浙江工业大学 2024-11-01 CN disclosed
US-20230129254-A1 METHODS OF TREATMENT OF PARTIAL ONSET SEIZURES USING ESLICARBAZEPINE ACETATE BIAL PORTELA & CA SA (PT) 2023-04-27 US disclosed
US-11364247-B2 Methods of treatment of partial onset seizures using eslicarbazepine acetate BIAL-PORTELA & CA S.A. (PT) 2022-06-21 US disclosed
US-20210154203-A1 METHODS OF TREATMENT OF PARTIAL ONSET SEIZURES USING ESLICARBAZEPINE ACETATE BIAL-PORTELIA & CA, S.A. (PT) 2021-05-27 US disclosed
WO-2021073231-A1 PREPARATION METHOD FOR ESLICARBAZEPINE 浙江九洲药业股份有限公司 2021-04-22 WO disclosed
EP-3680233-A1 NOVEL AMIDE COMPOUND, AND Pin1 INHIBITOR, THERAPEUTIC AGENT FOR INFLAMMATORY DISEASES AND THERAPEUTIC AGENT FOR CANCER THAT USE THE SAME Hiroshima University (JP) 2020-07-15 EP disclosed
US-10702536-B2 Methods of treatment of partial onset seizures using eslicarbazepine acetate BIAL-PORTELA & CA S.A. (PT) 2020-07-07 US disclosed
US-10695354-B2 Methods of treatment of partial onset seizures using eslicarbazepine acetate BIAL-PORTELA & CA S.A. (PT) 2020-06-30 US disclosed
EP-1004566-A2 Process for oxidation of substrates containing methyl, methylene or methin groups DSM Fine Chemicals Austria GmbH (AT) 2000-05-31 EP disclosed
US-5665543-A Method of discovering chemicals capable of functioning as gene expression modulators ONCOGENE SCIENCE, INC. (US) 1997-09-09 US disclosed
JP-H0761930-A INHIBITOR OF CANCER METASTASIS NIPPON ZEON CO LTD 1995-03-07 JP disclosed
EP-0483249-A4 1994-04-06 EP disclosed
WO-1992013092-A1 METHODS OF TRANSCRIPTIONALLY MODULATING EXPRESSION OF HEMATOPOIETIC GROWTH FACTOR GENES ONCOGENE SCIENCE, INC. (US) 1992-08-06 WO disclosed
WO-1992013063-A1 METHODS OF TRANSCRIPTIONALLY MODULATING EXPRESSION OF GROWTH FACTOR GENES AND GROWTH FACTOR RECEPTOR GENES ONCOGENE SCIENCE, INC. (US) 1992-08-06 WO disclosed
EP-0483249-A1 METHOD OF TRANSCRIPTIONALLY MODULATING GENE EXPRESSION AND OF DISCOVERING CHEMICALS CAPABLE OF FUNCTIONING AS GENE EXPRESSION MODULATORS Oncogene Science, Inc. (US) 1992-05-06 EP disclosed
WO-1991001379-A1 METHOD OF TRANSCRIPTIONALLY MODULATING GENE EXPRESSION AND OF DISCOVERING CHEMICALS CAPABLE OF FUNCTIONING AS GENE EXPRESSION MODULATORS ONCOGENE SCIENCE, INC. (US) 1991-02-07 WO disclosed
EP-0108715-A1 Dibenzazepine carboxamides CIBA-GEIGY AG (CH) 1984-05-16 EP disclosed