Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 16/20 | 0.65 |
| ▸ | HTR2A | P28223 | 13/20 | 0.65 |
| ▸ | HTR2B | P41595 | 11/20 | 0.65 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL170444 | 0.94 | HTR2C (0.74) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Adipic Acid SCHEMBL173678 | 0.88 | HTR2C (0.70) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Malonic Acid SCHEMBL174816 | 0.85 | HTR2C (0.74) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Glycolic Acid SCHEMBL173573 | 0.85 | HTR2C (0.74) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Lorcaserin SCHEMBL173294 | 0.84 | HTR2A (0.67) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Alpha-Ketoglutaric Acid SCHEMBL162746 | 0.83 | TAAR1 (0.42) | HTR2CHTR2AHTR2BADRA2CTAAR1 | |
| Glutamic Acid SCHEMBL174564 | 0.81 | HTR2C (0.59) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Alpha-Ketoglutaric Acid SCHEMBL16464850 | 0.81 | HTR2C (0.53) | HTR2CHTR2BTSHRNPSR1DRD2 | |
| SCHEMBL164205 | 0.81 | HTR2C (1.00) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Fumaric Acid SCHEMBL175130 | 0.80 | HTR2C (0.74) | HTR2CHTR2AHTR2BADRB1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611449-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030939-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |