Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 15/20 | 0.59 |
| ▸ | HTR2A | P28223 | 12/20 | 0.59 |
| ▸ | HTR2B | P41595 | 10/20 | 0.59 |
| ▸ | GRM8 | O00222 | 1/20 | 0.41 |
| ▸ | GRM6 | O15303 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL170444 | 0.87 | HTR2C (0.74) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Lorcaserin SCHEMBL15389716 | 0.86 | HTR2A (0.62) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Lorcaserin SCHEMBL174027 | 0.86 | HTR2A (0.62) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Lorcaserin SCHEMBL175743 | 0.86 | HTR2A (0.62) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Glutamic Acid SCHEMBL161669 | 0.84 | GRM8 (0.39) | HTR2CHTR2AHTR2BGRM8GRM6 | |
| Glutamic Acid SCHEMBL158772 | 0.84 | GRM8 (0.39) | HTR2CHTR2AHTR2BGRM8GRM6 | |
| Adipic Acid SCHEMBL173678 | 0.84 | HTR2C (0.70) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Glycolic Acid SCHEMBL173573 | 0.81 | HTR2C (0.74) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Malonic Acid SCHEMBL174816 | 0.81 | HTR2C (0.74) | HTR2CHTR2AHTR2BADRB1HTR1A | |
| Alpha-Ketoglutaric Acid SCHEMBL174469 | 0.81 | HTR2C (0.65) | HTR2CHTR2AHTR2BADRB1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611449-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030939-A1 | ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |