Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.38 |
| ▸ | EGFR | P00533 | 6/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17447921 | 1.00 | BTK (0.38) | BTKEGFR | |
| SCHEMBL17447941 | 1.00 | BTK (0.38) | BTKEGFR | |
| SCHEMBL17447828 | 0.95 | BTK (0.37) | BTKEGFR | |
| SCHEMBL17447998 | 0.90 | BTK (0.40) | BTKEGFR | |
| SCHEMBL17447963 | 0.90 | BTK (0.39) | BTKEGFR | |
| SCHEMBL17447797 | 0.88 | BTK (0.33) | BTKEGFR | |
| SCHEMBL17447960 | 0.88 | BTK (0.38) | BTKEGFR | |
| SCHEMBL17447783 | 0.88 | BTK (0.36) | BTKEGFR | |
| SCHEMBL17447810 | 0.86 | HDAC1 (0.35) | BTKEGFR | |
| SCHEMBL17447927 | 0.83 | LMNA (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016008411-A1 | 5-AMINO-4-CARBAMOYL-PYRAZOLE COMPOUNDS AS SELECTIVE AND IRREVERSIBLE T790M OVER WT-EGFR KINASE INHIBITORS AND USE THEREOF | BEIGENE, LTD. (KY) | 2016-01-21 | — | — | WO | disclosed |