Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B3 | P37058 | 7/20 | 0.38 |
| ▸ | FRK | P42685 | 1/20 | 0.37 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.37 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.37 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | STS | P08842 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4918277 | 0.85 | HSD17B3 (0.40) | CYP2C19HSD17B3FRKCAMK2BCAMK2G | |
| SCHEMBL4913283 | 0.80 | HPGD (0.42) | CYP2C19HSD17B3L3MBTL1HPGDSMN1; SMN2 | |
| SCHEMBL3639107 | 0.72 | FRK (0.47) | CYP2C19HSD17B3FRKCAMK2BCAMK2G | |
| SCHEMBL4917945 | 0.72 | SMN1; SMN2 (0.40) | CYP2C19HSD17B3L3MBTL1HPGDSMN1; SMN2 | |
| SCHEMBL4915288 | 0.71 | HSD17B3 (0.40) | CYP2C19HSD17B3FRKCAMK2BCAMK2G | |
| SCHEMBL4913661 | 0.69 | MMP1 (0.40) | CYP2C19L3MBTL1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL18748246 | 0.68 | HSD17B3 (0.56) | HSD17B3L3MBTL1HPGDSMN1; SMN2THRA | |
| SCHEMBL4922084 | 0.68 | HSD17B3 (0.40) | CYP2C19HSD17B3FRKCAMK2BCAMK2G | |
| SCHEMBL4911780 | 0.68 | HSD17B3 (0.40) | CYP2C19HSD17B3FRKCAMK2BCAMK2G | |
| SCHEMBL4913265 | 0.68 | FRK (0.43) | HSD17B3FRKCAMK2BCAMK2GCAMK2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242933-B2 | Heterocyclic compounds as positive modulators of metabotropic glutamate receptor 2 (mGlu2 receptor) | AbbVie Deutschland GmbH & Co. KG (DE) | 2016-01-26 | — | — | US | claimed |