Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.55 |
| ▸ | FLT1 | P17948 | 5/20 | 0.55 |
| ▸ | FLT4 | P35916 | 4/20 | 0.55 |
| ▸ | ACVR1 | Q04771 | 7/20 | 0.52 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.52 |
| ▸ | BMP4 | P12644 | 4/20 | 0.52 |
| ▸ | BMPR1B | O00238 | 3/20 | 0.52 |
| ▸ | BMPR1A | P36894 | 3/20 | 0.52 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.52 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.52 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.52 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.52 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.52 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.52 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.52 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | YES1 | P07947 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17442320 | 0.88 | KDR (0.61) | KDRFLT1FLT4ACVR1ACVRL1 | |
| SCHEMBL26867332 | 0.88 | KDR (0.52) | KDRFLT1FLT4ACVR1ACVRL1 | |
| SCHEMBL24409648 | 0.87 | KDR (0.51) | KDRFLT1FLT4ACVR1ACVRL1 | |
| SCHEMBL23988897 | 0.87 | KDR (0.51) | KDRFLT1FLT4ACVR1ACVRL1 | |
| SCHEMBL26867388 | 0.87 | KDR (0.51) | KDRFLT1FLT4ACVR1ACVRL1 | |
| SCHEMBL17442071 | 0.86 | KDR (0.53) | KDRFLT1FLT4ACVR1ACVRL1 | |
| SCHEMBL17442204 | 0.86 | KDR (0.53) | KDRFLT1FLT4ACVR1ACVRL1 | |
| SCHEMBL17442043 | 0.86 | ACVR1 (0.54) | KDRFLT1FLT4ACVR1ACVRL1 | |
| SCHEMBL24409643 | 0.86 | KDR (0.50) | KDRFLT1FLT4ACVR1ACVRL1 | |
| SCHEMBL24409695 | 0.86 | KDR (0.52) | KDRFLT1FLT4ACVR1ACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016011019-A1 | COMPOSITIONS AND METHODS FOR INHIBITING BMP | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2016-01-21 | — | — | WO | disclosed |