Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.50 |
| ▸ | FLT1 | P17948 | 7/20 | 0.50 |
| ▸ | FLT4 | P35916 | 5/20 | 0.50 |
| ▸ | ACVR1 | Q04771 | 7/20 | 0.48 |
| ▸ | PRKAB2 | O43741 | 5/20 | 0.48 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.48 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.48 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.48 |
| ▸ | PRKAG3 | Q9UGI9 | 5/20 | 0.48 |
| ▸ | PRKAG2 | Q9UGJ0 | 5/20 | 0.48 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.48 |
| ▸ | BMP4 | P12644 | 4/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 3/20 | 0.48 |
| ▸ | BMPR1A | P36894 | 3/20 | 0.48 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.48 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.48 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24409648 | 0.99 | KDR (0.51) | KDRFLT1FLT4ACVR1PRKAB2 | |
| SCHEMBL24409634 | 0.92 | PRKAB1 (0.56) | KDRFLT1FLT4ACVR1PRKAB2 | |
| SCHEMBL24409624 | 0.90 | KDR (0.43) | KDRFLT1FLT4ACVR1PRKAB2 | |
| SCHEMBL24409786 | 0.90 | KDR (0.50) | KDRFLT1FLT4ACVR1PRKAB2 | |
| SCHEMBL24409683 | 0.90 | KDR (0.50) | KDRFLT1FLT4ACVR1PRKAB2 | |
| SCHEMBL24409783 | 0.90 | ACVR1 (0.55) | KDRFLT1FLT4ACVR1PRKAB2 | |
| SCHEMBL24409705 | 0.89 | KDR (0.42) | KDRFLT1FLT4ACVR1PRKAB2 | |
| SCHEMBL24409771 | 0.88 | KDR (0.49) | KDRFLT1FLT4ACVR1PRKAB2 | |
| SCHEMBL24409700 | 0.87 | FLT1 (0.67) | KDRFLT1FLT4ACVR1PRKAB2 | |
| SCHEMBL24409810 | 0.87 | KDR (0.40) | KDRFLT1FLT4ACVR1PRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081212-A1 | METHODS OF USING ALK2 INHIBITORS | KEROS THERAPEUTICS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2022099166-A1 | METHODS OF TREATING CARDIOVASCULAR-RELATED DISEASE | KEROS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |
| WO-2022098812-A1 | METHODS OF TREATING IRON OVERLOAD | KEROS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |
| WO-2022098821-A1 | METHODS OF TREATING LYMPHOPENIA | KEROS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |