Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 14/20 | 0.72 |
| ▸ | ACVRL1 | P37023 | 8/20 | 0.54 |
| ▸ | BMPR1B | O00238 | 7/20 | 0.54 |
| ▸ | BMPR1A | P36894 | 6/20 | 0.54 |
| ▸ | BMP4 | P12644 | 5/20 | 0.53 |
| ▸ | ACVR1B | P36896 | 6/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.50 |
| ▸ | TGFBR2 | P37173 | 4/20 | 0.50 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.50 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.48 |
| ▸ | BMPR2 | Q13873 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19110562 | 0.86 | ACVR1 (0.72) | ACVR1ACVRL1BMPR1BBMPR1ABMP4 | |
| SCHEMBL24409829 | 0.85 | ACVR1 (0.71) | ACVR1ACVRL1BMPR1BBMPR1ABMP4 | |
| SCHEMBL17448515 | 0.84 | BMP4 (0.74) | ACVR1ACVRL1BMPR1BBMPR1ABMP4 | |
| SCHEMBL23988780 | 0.84 | ACVR1 (0.70) | ACVR1ACVRL1BMPR1BBMPR1ABMP4 | |
| SCHEMBL19123596 | 0.84 | ACVR1 (0.69) | ACVR1ACVRL1BMPR1BBMPR1ABMP4 | |
| SCHEMBL17448650 | 0.84 | BMP4 (0.76) | ACVR1ACVRL1BMPR1BBMPR1ABMP4 | |
| SCHEMBL17442224 | 0.84 | ACVR1 (1.00) | ACVR1ACVRL1BMPR1BBMPR1ABMP4 | |
| SCHEMBL17448674 | 0.82 | BMP4 (0.54) | ACVR1ACVRL1BMPR1BBMPR1ABMP4 | |
| SCHEMBL17448673 | 0.81 | BMP4 (0.56) | ACVR1ACVRL1BMPR1BBMPR1ABMP4 | |
| SCHEMBL17448662 | 0.81 | ACVR1 (0.74) | ACVR1ACVRL1BMPR1BBMPR1ABMP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016011019-A1 | COMPOSITIONS AND METHODS FOR INHIBITING BMP | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2016-01-21 | — | — | WO | disclosed |