SCHEMBL1745123

SCHEMBL1745123

CCC(Cc1ccc(OC/C=C(/c2ccc(Cl)cc2)c2ccc(I)cc2)cc1C)C(=O)O

nearest known ligand 0.43

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PPARG P37231 19/20 0.43
PPARA Q07869 16/20 0.43
PPARD Q03181 14/20 0.43
EPHX2 P34913 4/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1745182 0.91 PPARD (0.51) PPARGPPARAPPARDEPHX2
SCHEMBL4325528 0.82 PPARD (0.47) PPARGPPARAPPARD
SCHEMBL4325534 0.81 PPARD (0.41) PPARGPPARAPPARD
SCHEMBL4325522 0.81 PPARD (0.41) PPARGPPARAPPARD
SCHEMBL1747437 0.80 KDM4E (0.44) PPARGPPARAPPARD
SCHEMBL1746469 0.80 KDM4E (0.44) PPARGPPARAPPARD
SCHEMBL1745125 0.79 PPARD (0.39) PPARGPPARAPPARD
SCHEMBL1747388 0.79 TSHR (0.53) PPARGPPARAPPARD
SCHEMBL1744326 0.79 TSHR (0.53) PPARGPPARAPPARD
SCHEMBL1744324 0.79 TSHR (0.53) PPARGPPARAPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2386540-A1 Novel compounds, their preparation and use High Point Pharmaceuticals, LLC (US) 2011-11-16 EP disclosed
US-20110245244-A1 PHENOXY ACETIC ACIDS AS PPAR DELTA ACTIVATORS HIGH POINT PHARMACEUTICALS, LLC (US) 2011-10-06 US disclosed
US-7943613-B2 Compounds, their preparation and use HIGH POINT PHARMACEUTICALS, LLC (US) 2011-05-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110245244-A1 PHENOXY ACETIC ACIDS AS PPAR DELTA ACTIVATORS PPARG, PPARA, PPARD PPARG 1/4885PPARA 2/4885PPARD 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.