SCHEMBL1745182

SCHEMBL1745182

CCC(Cc1ccc(OC/C=C(\c2ccc(Cl)cc2)c2ccc(Br)cc2)cc1C)C(=O)O

nearest known ligand 0.51

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 19/20 0.51
PPARG P37231 14/20 0.51
PPARA Q07869 13/20 0.51
EPHX2 P34913 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1745123 0.91 PPARG (0.43) PPARDPPARGPPARAEPHX2
SCHEMBL4334798 0.82 PPARD (0.61) PPARDPPARGPPARA
SCHEMBL4334801 0.82 PPARD (0.61) PPARDPPARGPPARA
SCHEMBL9903706 0.81 PPARD (0.49) PPARDPPARGPPARA
SCHEMBL4334803 0.81 PPARD (0.49) PPARDPPARGPPARA
SCHEMBL1747437 0.80 KDM4E (0.44) PPARDPPARGPPARA
SCHEMBL1746469 0.80 KDM4E (0.44) PPARDPPARGPPARA
SCHEMBL1745168 0.79 TSHR (0.53) PPARDPPARGPPARA
SCHEMBL1745169 0.79 TSHR (0.53) PPARDPPARGPPARA
SCHEMBL1745170 0.79 TSHR (0.53) PPARDPPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2386540-A1 Novel compounds, their preparation and use High Point Pharmaceuticals, LLC (US) 2011-11-16 EP disclosed
US-20110245244-A1 PHENOXY ACETIC ACIDS AS PPAR DELTA ACTIVATORS HIGH POINT PHARMACEUTICALS, LLC (US) 2011-10-06 US disclosed
US-7943613-B2 Compounds, their preparation and use HIGH POINT PHARMACEUTICALS, LLC (US) 2011-05-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110245244-A1 PHENOXY ACETIC ACIDS AS PPAR DELTA ACTIVATORS PPARG, PPARA, PPARD PPARD 3/4885PPARG 1/4885PPARA 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.