Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.50 |
| ▸ | JAK3 | P52333 | 11/20 | 0.47 |
| ▸ | JAK1 | P23458 | 4/20 | 0.47 |
| ▸ | TYK2 | P29597 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 2/20 | 0.47 |
| ▸ | CIT | O14578 | 2/20 | 0.47 |
| ▸ | GAK | O14976 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.47 |
| ▸ | MARK3 | P27448 | 2/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.47 |
| ▸ | NEK3 | P51956 | 2/20 | 0.47 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2356073 | 0.91 | JAK2 (0.54) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL2359102 | 0.82 | JAK2 (0.54) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL3307295 | 0.81 | JAK2 (0.51) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL13846212 | 0.80 | JAK2 (0.48) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL3711778 | 0.80 | JAK2 (0.49) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL2356895 | 0.79 | CDK2 (0.51) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL2356388 | 0.79 | JAK2 (0.58) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL13846262 | 0.78 | JAK2 (0.44) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL13846274 | 0.78 | JAK2 (0.56) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL3719159 | 0.78 | JAK2 (0.46) | JAK2JAK3JAK1TYK2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220068-B1 | 4-PYRAZOLYL-N-ARYLPYRIMIDIN-2-AMINES AND 4-PYRAZOLYL-N-HETEROARYLPYRIMIDIN-2-AMINES AS JANUS KINASE INHIBITORS | INCYTE HOLDINGS CORP (US) | 2016-01-27 | — | — | EP | disclosed |