Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.56 |
| ▸ | JAK3 | P52333 | 7/20 | 0.51 |
| ▸ | JAK1 | P23458 | 3/20 | 0.49 |
| ▸ | TYK2 | P29597 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3709983 | 0.89 | JAK2 (0.56) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL2356388 | 0.87 | JAK2 (0.58) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL13846212 | 0.87 | JAK2 (0.48) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL2358356 | 0.85 | JAK2 (0.55) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL2358412 | 0.85 | JAK2 (0.55) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL13846209 | 0.84 | CDK2 (0.48) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL13846262 | 0.83 | JAK2 (0.44) | JAK2JAK3JAK1TYK2HDAC3 | |
| SCHEMBL2358315 | 0.83 | JAK2 (0.55) | JAK2JAK3JAK1TYK2HDAC1 | |
| Hydrochloric Acid SCHEMBL4410217 | 0.82 | JAK2 (0.54) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL13846361 | 0.82 | CDK1 (0.43) | JAK2JAK3JAK1TYK2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009064835-A1 | 4-PYRAZOLYL-N-ARYLPYRIMIDIN-2-AMINES AND 4-PYRAZOLYL-N-HETEROARYLPYRIMIDIN-2-AMINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-05-22 | — | — | WO | disclosed |