Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 16/20 | 0.55 |
| ▸ | JAK1 | P23458 | 13/20 | 0.55 |
| ▸ | JAK3 | P52333 | 10/20 | 0.55 |
| ▸ | TYK2 | P29597 | 5/20 | 0.55 |
| ▸ | ABL1 | P00519 | 3/20 | 0.55 |
| ▸ | GSK3B | P49841 | 2/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.55 |
| ▸ | STAT3 | P40763 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.46 |
| ▸ | PAK4 | O96013 | 2/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.46 |
| ▸ | LTK | P29376 | 2/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.46 |
| ▸ | CLK2 | P49760 | 2/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3310525 | 0.93 | CCNE1 (0.58) | CCNE1CDK2JAK2JAK1JAK3 | |
| SCHEMBL3306077 | 0.92 | CCNE1 (0.54) | CCNE1CDK2JAK2JAK1JAK3 | |
| SCHEMBL17451314 | 0.92 | ABL1 (0.53) | CCNE1CDK2JAK2JAK1JAK3 | |
| SCHEMBL3302295 | 0.92 | CDK2 (0.56) | CCNE1CDK2JAK2JAK1JAK3 | |
| SCHEMBL2356289 | 0.90 | JAK2 (0.58) | CCNE1CDK2JAK2JAK1JAK3 | |
| SCHEMBL2359386 | 0.89 | CDK2 (0.56) | CCNE1CDK2JAK2JAK1JAK3 | |
| SCHEMBL3311232 | 0.89 | CCNE1 (0.52) | CCNE1CDK2JAK2JAK1JAK3 | |
| SCHEMBL2359287 | 0.89 | CCNE1 (0.52) | CCNE1CDK2JAK2JAK1JAK3 | |
| SCHEMBL3310363 | 0.89 | CDK2 (0.53) | CCNE1CDK2JAK2JAK1JAK3 | |
| SCHEMBL3307521 | 0.89 | CCNE1 (0.54) | CCNE1CDK2JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220068-B1 | 4-PYRAZOLYL-N-ARYLPYRIMIDIN-2-AMINES AND 4-PYRAZOLYL-N-HETEROARYLPYRIMIDIN-2-AMINES AS JANUS KINASE INHIBITORS | INCYTE HOLDINGS CORP (US) | 2016-01-27 | — | — | EP | claimed |